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Targeting the TLR4–MD2 axis in systemic sclerosis

Nature Reviews Rheumatologyvolume 14pages564566 (2018) | Download Citation

Inappropriate activation of Toll-like receptor 4 (TLR4) on resident fibroblasts, through the binding of damage-associated molecular patterns, is a potential driver of fibrosis in systemic sclerosis. New evidence suggests that targeting fibroblast-specific TLR4 or an accessory molecule MD2 could have therapeutic value.

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Author information


  1. Northumbria University, Faculty of Health and Life Sciences, Ellison Building, Newcastle Upon Tyne, UK

    • Steven O’Reilly
  2. University Medical Centre Utrecht, Department of Rheumatology and Immunology, Utrecht, Netherlands

    • Jacob M. van Laar


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Competing interests

The authors declare no competing interests.

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Correspondence to Steven O’Reilly.

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