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TRAUMATIC BRAIN INJURY

Risk of dementia after TBI — a cause of growing concern

Nature Reviews Neurology volume 14, pages 511–512 (2018)Cite this article

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Moderate and severe traumatic brain injuries (TBIs) have long been recognized as risk factors for dementia, but the relationship between mild TBI (mTBI) and dementia is unclear. New research demonstrates that even an mTBI without loss of consciousness is associated with a twofold increase in the risk of dementia.

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References

  1. Levin, H. S., Benton, A. L. & Grossman, R. G. Neurobehavioral Consequences of Closed Head Injury (Oxford Univ. Press, 1982).

  2. Defense and Veterans Brain Injury Center. DoD numbers for traumatic brain injury. DVBIC http://dvbic.dcoe.mil/files/tbi-numbers/worldwide-totals-2017-Q1-Q4_feb-14-2018_v1.0_2018-03-08_0.pdf (2017).

  3. Nordström, A. & Nordström, P. Traumatic brain injury and the risk of dementia diagnosis: a nationwide cohort study. PLoS Med. 15, e1002496 (2018).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Sofko, C. A., Currier, J. M., Hill, B. D. & Drescher, K. D. History of loss of consciousness with mild traumatic brain injury affects PTSD symptom presentation in treatment-seeking Iraq/Afghanistan veterans. Brain Inj. 30, 1561–1569 (2016).

    Article  PubMed  Google Scholar 

  5. Barnes, D. E. et al. Association of mild traumatic brain injury with and without loss of consciousness with dementia in US military veterans. JAMA Neurol. 94121, E1–E7 (2018).

    Google Scholar 

  6. Raymont, V., Salazar, A. M., Krueger, F. & Grafman, J. ‘Studying injured minds’ – the Vietnam Head Injury Study and 40 years of brain injury research. Front. Neurol. 2, 1–13 (2011).

    Article  Google Scholar 

  7. Ruff, R. L., Riechers, R. G., Wang, X.-F., Piero, T. & Ruff, S. S. A case–control study examining whether neurological deficits and PTSD in combat veterans are related to episodes of mild TBI. BMJ Open 2, e000312 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  8. McKee, A. C. et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 136, 43–64 (2013).

    Article  PubMed  Google Scholar 

  9. Helmick, K. M. et al. Traumatic brain injury in the US military: epidemiology and key clinical and research programs. Brain Imaging Behav. 9, 358–366 (2015).

    Article  PubMed  Google Scholar 

  10. Weiner, M. W. et al. Effects of traumatic brain injury and posttraumatic stress disorder on development of Alzheimer’s disease in Vietnam Veterans using the Alzheimer’s Disease Neuroimaging Initiative: preliminary report. Alzheimers Dement. (N. Y.) 3, 177–188 (2017).

    Google Scholar 

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  1. National Institutes of Health, National Institute of Nursing Research, Bethesda, MD, USA

    Cassandra L. Pattinson & Jessica M. Gill

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  1. Cassandra L. Pattinson
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  2. Jessica M. Gill
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Correspondence to Jessica M. Gill.

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The authors declare no competing interests.

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Pattinson, C.L., Gill, J.M. Risk of dementia after TBI — a cause of growing concern. Nat Rev Neurol 14, 511–512 (2018). https://doi.org/10.1038/s41582-018-0041-8

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