The clinical relevance of minor histocompatibility antigens in transplantation is disputed. High-throughput approaches are now being used to investigate the role of genome-wide genetic incompatibility in transplant outcomes. A recent study reports that donor and recipient mismatch at the LIMS1 locus is associated with an increased risk of acute rejection.
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Acknowledgements
We acknowledge the generous help of A. Heinzel (Medical University of Vienna, Austria) in preparing this article. This work was supported by the Vienna Science and Technology Fund WWTF (grant # LS16-019 and # LS18-031) and the Österreichisch Nationalbank (grant # 17289).
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Reindl-Schwaighofer, R., Oberbauer, R. Histocompatibility: minor differences have a major impact. Nat Rev Nephrol 15, 529–530 (2019). https://doi.org/10.1038/s41581-019-0175-y
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DOI: https://doi.org/10.1038/s41581-019-0175-y
