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GENETICS

Cellular recording devices imprint the history of the cell

Nature Reviews Nephrology volume 14, pages 477–478 (2018)Cite this article

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Technologies such as proteomics provide a snapshot of a specific cellular state but are unable to directly record successive signalling events. Two new CRISPR-mediated analogue multi-event recording apparatus (CAMERA) systems enable sequential recording of endogenous and exogenous signalling events by targeted DNA modifications, thereby allowing systematic interrogation of different cellular states.

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References

  1. Hasin, Y., Seldin, M. & Lusis, A. Multi-omics approaches to disease. Genome Biol. 18, 83 (2017).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  2. Tang, W. & Liu, D. R. Rewritable multi-event analog recording in bacterial and mammalian cells. Science https://doi.org/10.1126/science.aap8992 (2018).

  3. Clevers, H. & Nusse, R. Wnt/beta-catenin signaling and disease. Cell 149, 1192–1205 (2012).

    Article  PubMed  CAS  Google Scholar 

  4. Schmidt-Ott, K. M. & Barasch, J. WNT/beta-catenin signaling in nephron progenitors and their epithelial progeny. Kidney Int. 74, 1004–1008 (2008).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  5. Kawakami, T., Ren, S. & Duffield, J. S. Wnt signalling in kidney diseases: dual roles in renal injury and repair. J. Pathol. 229, 221–231 (2013).

    Article  PubMed  CAS  Google Scholar 

  6. Tiong, H. Y. et al. Drug-induced nephrotoxicity: clinical impact and preclinical in vitro models. Mol. Pharm. 11, 1933–1948 (2014).

    Article  PubMed  CAS  Google Scholar 

  7. Papadimitriou, J. C. et al. BK polyomavirus infection and renourinary tumorigenesis. Am. J. Transplant. 16, 398–406 (2016).

    Article  PubMed  CAS  Google Scholar 

  8. Pfeifer, G. P. & Besaratinia, A. Mutational spectra of human cancer. Hum. Genet. 125, 493–506 (2009).

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  9. Jurado-Escobar, R. et al. Update on the genetic basis of drug hypersensitivity reactions. J. Investig. Allergol. Clin. Immunol. 27, 336–345 (2017).

    Article  PubMed  CAS  Google Scholar 

  10. Sheth, R. U., Yim, S. S., Wu, F. L. & Wang, H. H. Multiplex recording of cellular events over time on CRISPR biological tape. Science 358, 1457–1461 (2017).

    Article  PubMed  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Division of Nephrology, Department of Medicine, Columbia University Medical Center, Russ Berrie Pavilion, New York, NY, USA

    Nicholas J. Steers & Ali G. Gharavi

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  1. Nicholas J. Steers
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  2. Ali G. Gharavi
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Correspondence to Ali G. Gharavi.

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The authors declare no competing interests.

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Steers, N.J., Gharavi, A.G. Cellular recording devices imprint the history of the cell. Nat Rev Nephrol 14, 477–478 (2018). https://doi.org/10.1038/s41581-018-0012-8

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