Genome Watch

Juggling resistance mutations

This month’s Genome Watch discusses how a better understanding of the genetic mechanisms of antimalarial drug resistance can maximize the utility of genomic surveillance programs in informing the most effective drug policy.

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  1. 1.

    Imwong, M. et al. The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: a molecular epidemiology observational study. Lancet Infect. Dis. 17, 491–497 (2017).

  2. 2.

    Amato, R. et al. Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study. Lancet Infect. Dis. 18, 337–345 (2018).

  3. 3.

    Cowell, A. N. et al. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science 359, 191–199 (2018).

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Author information


  1. Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK

    • Gavin G. Rutledge
    •  & Roberto Amato


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Competing interests

The authors declare no competing interests.

Corresponding author

Correspondence to Gavin G. Rutledge.