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LIVER CANCER

Gut microbiota as gatekeeper of anti-tumour responses in the liver

A new report in Science by Ma and colleagues uncovers the interplay of microbiota-controlled bile acid metabolism and immune responses in the context of primary and metastatic liver tumours in mice. Their findings shed light on the gut–liver axis in hepatic malignancies.

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Fig. 1: Microbiota-derived bile acids modulate immune cell anti-tumour functions.

References

  1. Adolph, T. E. et al. Liver–microbiome axis in health and disease. Trends Immunol. https://doi.org/10.1016/j.it.2018.05.002 (2018).

    Article  PubMed  Google Scholar 

  2. Jia, W., Xie, G. & Jia, W. Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nat. Rev. Gastroenterol. Hepatol. 15, 111–128 (2018).

    Article  CAS  Google Scholar 

  3. Ma, C. et al. Gut microbiome-mediated bile acid metabolism regulates liver cancer via NKT cells. Science 360, eaan5931 (2018).

    Article  Google Scholar 

  4. Dapito, D. H. et al. Promotion of hepatocellular carcinoma by the intestinal microbiota and TLR4. Cancer Cell 21, 504–516 (2012).

    Article  CAS  Google Scholar 

  5. Ponziani, F. R. et al. Hepatocellular carcinoma is associated with gut microbiota profile and inflammation in non-alcoholic fatty liver disease. Hepatology https://doi.org/10.1002/hep.30036 (2018).

    Article  PubMed  Google Scholar 

  6. Bullman, S. et al. Analysis of Fusobacterium persistence and antibiotic response in colorectal cancer. Science 358, 1443–1448 (2017).

    Article  CAS  Google Scholar 

  7. Sivan, A. et al. Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy. Science 350, 1084–1089 (2015).

    Article  CAS  Google Scholar 

  8. Routy, B. et al. Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors. Science 359, 91–97 (2018).

    Article  CAS  Google Scholar 

  9. Gopalakrishnan, V. et al. Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients. Science 359, 97–103 (2018).

    Article  CAS  Google Scholar 

  10. Shalapour, S. et al. Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity. Nature 551, 340–345 (2017).

    Article  CAS  Google Scholar 

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Correspondence to Herbert Tilg.

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Adolph, T.E., Tilg, H. Gut microbiota as gatekeeper of anti-tumour responses in the liver. Nat Rev Gastroenterol Hepatol 15, 584–586 (2018). https://doi.org/10.1038/s41575-018-0046-1

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