Alterations in lipid metabolism are closely linked to disorders such as cardiovascular disease, type 2 diabetes mellitus and non-alcoholic fatty liver disease. A multi-omics study on a mouse genetic reference panel uncovers regulatory networks and potential biomarkers of hepatic lipid metabolism.
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References
Younossi, Z. et al. Global burden of NAFLD and NASH: trends, predictions, risk factors and prevention. Nat. Rev. Gastroenterol. Hepatol. 15, 11–20 (2018).
World Health Organization. Cardiovascular diseases (CVDs). WHO https://www.who.int/en/news-room/fact-sheets/detail/cardiovascular-diseases-(cvds) (2017).
Parker, B. L. et al. An integrative systems genetic analysis of mammalian lipid metabolism. Nature 567, 187–193 (2019).
Hui, S. T. et al. The genetic architecture of diet-induced hepatic fibrosis in mice. Hepatology 68, 2182–2196 (2018).
Hui, S. T. et al. The genetic architecture of NAFLD among inbred strains of mice. eLife 4, e05607 (2015).
Jha, P. et al. Systems analyses reveal physiological roles and genetic regulators of liver lipid species. Cell Syst. 6, 722–733 (2018).
Jha, P. et al. Genetic regulation of plasma lipid species and their association with metabolic phenotypes. Cell Syst. 6, 709–721 (2018).
Gragnoli, C. PSMD9 gene in the NIDDM2 locus is linked to type 2 diabetes in Italians. J. Cell. Physiol. 222, 265–267 (2010).
European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD) & European Association for the Study of Obesity (EASO). EASL-EASD-EASO clinical practice guidelines for the management of non-alcoholic fatty liver disease. J. Hepatol. 64, 1388–1402 (2016).
Chalasani, N. et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology 67, 328–357 (2018).
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Haas, J.T., Staels, B. Understanding lipid metabolism through hepatic steat-omics. Nat Rev Endocrinol 15, 321–322 (2019). https://doi.org/10.1038/s41574-019-0203-9
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DOI: https://doi.org/10.1038/s41574-019-0203-9