New-onset atrial fibrillation (AF) is a common complication affecting patients who undergo aortic valve replacement (AVR) and transcatheter aortic valve implantation (TAVI), according to a population-based, observational study. The analysis included 48,715 patients admitted to hospital to receive TAVI and 122,765 to receive AVR. New-onset AF was observed in 50.4% of TAVI hospitalizations and 50.1% of AVR hospitalizations. Patients with new-onset AF also had a greater prevalence of coronary artery disease, congestive heart failure and peripheral vascular disease than those without new-onset AF. Furthermore, new-onset AF was associated with prolonged hospitalization and higher in-hospital mortality.