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MICROBIOME

Gut pathobionts as triggers for liver diseases

Nature Microbiology volume 4, pages 380–381 (2019)Cite this article

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Klebsiella pneumoniae isolated from patients with primary sclerosing cholangitis was found to cause intestinal barrier dysfunction resulting in T-helper-17-cell-mediated hepatobiliary injury, providing evidence for specific gut-derived, pore-forming pathogens as triggers for immune-mediated liver disease.

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Fig. 1: Schematic representation of the gut–liver axis in the pathogensis of PSC.

References

  1. Karlsen, T. H., Folseraas, T., Thorburn, D. & Vesterhus, M. J. Hepatol. 67, 1298–1323 (2017).

    Article  Google Scholar 

  2. Li, B., Selmi, C., Tang, R., Gershwin, M. E. & Ma, X. Cell. Mol. Immunol. 15, 595–609 (2018).

    Article  Google Scholar 

  3. Nakamoto. et al. Nat. Microbiol. https://doi.org/10.1038/s41564-018-0333–1 (2019).

    Article  PubMed  Google Scholar 

  4. Fickert, P. & Wagner, M. J. Hepatol. 67, 619–631 (2017).

    Article  CAS  Google Scholar 

  5. Hov, J. R. & Karlsen, T. H. Semin. Liver Dis. 37, 314–331 (2017).

    Article  Google Scholar 

  6. Fickert, P. et al. J. Hepatol. 60, 1290–303 (2014).

    Article  Google Scholar 

  7. Wahlström, A., Sayin, S. I., Marschall, H. U. & Bäckhed, F. Cell Metab. 24, 41–50 (2016).

    Article  Google Scholar 

  8. Damman, J. L. et al. Aliment. Pharm. Ther. 47, 886–895 (2018).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Gastroenterology and Hepatology, Medical University Graz, Graz, Austria

    Peter Fickert

  2. Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden

    Hanns-Ulrich Marschall

Authors
  1. Peter Fickert
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  2. Hanns-Ulrich Marschall
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Correspondence to Peter Fickert.

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The authors declare no competing interests.

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Fickert, P., Marschall, HU. Gut pathobionts as triggers for liver diseases. Nat Microbiol 4, 380–381 (2019). https://doi.org/10.1038/s41564-019-0388-7

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