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VIRAL CELL BIOLOGY

Stop HUSHing on SIV/HIV

Nature Microbiology volume 3, pages 1336–1338 (2018)Cite this article

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Primate immunodeficiency virus accessory proteins Vpx/Vpr associate with and induce proteasomal degradation of the HUSH complex, thereby counteracting HUSH-mediated epigenetic transcriptional repression of proviral and cellular genes. These findings open new therapeutic avenues against HIV.

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Fig. 1: Model for HUSH-mediated epigenetic silencing of HIV-1 transcription during latency and Vpx/Vpr-mediated reactivation through HUSH complex degradation.

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  1. Service of Molecular Virology, Department of Molecular Biology (DBM), Université Libre de Bruxelles (ULB), Gosselies, Belgium

    Carine Van Lint

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  1. Carine Van Lint
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Correspondence to Carine Van Lint.

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Van Lint, C. Stop HUSHing on SIV/HIV. Nat Microbiol 3, 1336–1338 (2018). https://doi.org/10.1038/s41564-018-0308-2

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