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BACTERIAL PATHOGENESIS

Breaching the wall

Protein translocation across bacterial membranes can take many routes through dedicated transport machines. A new study finds that Salmonella Typhi utilizes a distinct pathway to translocate typhoid toxin across the peptidoglycan layer and prime the bacterium for host intoxication.

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Fig. 1: Model of stepwise secretion of typhoid toxin.

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Correspondence to Anastassios Economou.

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Economou, A. Breaching the wall. Nat Microbiol 3, 1192–1193 (2018). https://doi.org/10.1038/s41564-018-0279-3

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