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BACTERIAL PATHOGENESIS

Streptococci target inflammasome

Nature Microbiology volume 2, pages 1334–1335 (2017)Cite this article

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The Streptococcus pyogenes surface M protein is a critical multifunctional virulence factor. Recent work sheds light on a new unexpected function of the M protein in activating the host inflammasome to induce macrophage cell death and promote infection.

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Fig. 1: M-protein-mediated GAS virulence strategies.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, 73104, USA

    Madeleine W. Cunningham

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  1. Madeleine W. Cunningham
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Correspondence to Madeleine W. Cunningham.

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Competing interests

The author declares financial interest in Moleculera Labs in Oklahoma City, OK, where she is Chief Scientific Officer.

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Cunningham, M.W. Streptococci target inflammasome. Nat Microbiol 2, 1334–1335 (2017). https://doi.org/10.1038/s41564-017-0031-4

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