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Gene targeting

CRISPR genome editing in stem cells turns to gold

Nature Materials volume 18, pages 1038–1039 (2019)Cite this article

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Hematopoietic stem and progenitor cells have been engineered using gold nanoformulations conjugated with CRISPR capable of targeting two distinct genomic loci of therapeutic interest, with potential engraftment in humanized mouse models.

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Fig. 1: Gold nanoparticle formulation for the delivery of gene editing machinery.

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Authors and Affiliations

  1. Department of Surgery, Duke University, Durham, NC, USA

    Aravind Asokan

  2. Department of Molecular Genetics and Microbiology, Duke University, Durham, NC, USA

    Aravind Asokan

  3. Department of Biomedical Engineering, Duke University, Durham, NC, USA

    Aravind Asokan

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  1. Aravind Asokan
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Correspondence to Aravind Asokan.

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Asokan, A. CRISPR genome editing in stem cells turns to gold. Nat. Mater. 18, 1038–1039 (2019). https://doi.org/10.1038/s41563-019-0491-4

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