Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Chromatin

A transient absence of SMC-mediated loops after mitosis

After mitosis chromosomes are drastically reshaped. A study now charts the dynamics of this conformational change at high temporal resolution. During the shift from one loop-forming complex (condensin) to another (cohesin), an intermediate chromosome folding state exists in which neither of these complexes are associated with chromatin.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Purchase on Springer Link

Instant access to full article PDF

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Loop organization during the transition from mitosis to interphase.

References

  1. Naumova, N. et al. Science 342, 948–953 (2013).

    Article  CAS  Google Scholar 

  2. Gibcus, J. H. et al. Science. 359, eaao6135 (2018).

    Article  Google Scholar 

  3. Abramo, K. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-019-0406-2 (2019).

    Article  Google Scholar 

  4. Nora, E. P. et al. Nature 485, 381–385 (2012).

    Article  CAS  Google Scholar 

  5. Dixon, J. R. et al. Nature 485, 376–380 (2012).

    Article  CAS  Google Scholar 

  6. Vietri Rudan, M. et al. Cell Rep. 10, 1297–1309 (2015).

    Article  CAS  Google Scholar 

  7. Lieberman-Aiden, E. et al. Science 326, 289–293 (2009).

    Article  CAS  Google Scholar 

  8. van Ruiten, M. S. & Rowland, B. D. Trends Genet. 34, 477–487 (2018).

    Article  Google Scholar 

  9. Ganji, M. et al. Science 360, 102–105 (2018).

    Article  CAS  Google Scholar 

  10. Haarhuis, J. H. I. et al. Cell 169, 693–707.e14 (2017).

    Article  CAS  Google Scholar 

  11. Schwarzer, W. et al. Nature 551, 51–56 (2017).

    Article  Google Scholar 

  12. de Wit, E. & de Laat, W. Genes Dev. 26, 11–24 (2012).

    Article  Google Scholar 

  13. Peters, J.-M., Tedeschi, A. & Schmitz, J. Genes Dev. 22, 3089–3114 (2008).

    Article  CAS  Google Scholar 

  14. Agarwal, H., Reisser, M., Wortmann, C. & Gebhardt, J. C. M. Biophys. J. 112, 2051–2055 (2017).

    Article  CAS  Google Scholar 

  15. Stevens, T. J. et al. Nature 544, 59–64 (2017).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Elzo de Wit.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, N.Q., de Wit, E. A transient absence of SMC-mediated loops after mitosis. Nat Cell Biol 21, 1303–1304 (2019). https://doi.org/10.1038/s41556-019-0421-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41556-019-0421-3

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing