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STEM CELLS

Improving human β-cell maturation in vitro

Nature Cell Biology volume 21, pages 119–121 (2019)Cite this article

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Patients with diabetes could benefit from cell-based insulin therapy, but the supply of human islet tissue is limited. A study now reports an approach in which human-pluripotent-stem-cell-derived islet β-cells are purified and re-aggregated to generate cells that more closely resemble mature human β-cells.

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Fig. 1: An improved protocol for human stem cell to β-cell differentiation in vitro.

References

  1. Global report on diabetes WHO 2016. https://www.who.int/diabetes/global-report/en/

  2. DiMeglio, L. A., Evans-Molina, C. & Oram, R. A. Lancet 391, 2449–2462 (2018).

    Article  Google Scholar 

  3. Muoio, D. M. & Newgard, C. B. Nat. Rev. Mol. Cell Biol. 9, 193–205 (2008).

    Article  CAS  Google Scholar 

  4. Shapiro, A. M., Pokrywczynska, M. & Ricordi, C. Nat. Rev. Endocrinol. 13, 268–277 (2017).

    Article  CAS  Google Scholar 

  5. Nair, G. G. et al. Nat. Cell Biol. https://doi.org/10.1038/s41556-018-0271-4 (2019).

  6. Pagliuca, F. W. et al. Cell 159, 428–439 (2014).

    Article  CAS  Google Scholar 

  7. Rezania, A. et al. Nat. Biotech. 32, 1121–1133 (2014).

    Article  CAS  Google Scholar 

  8. Russ, H. A. et al. EMBO J. 34, 1759–1772 (2015).

    Article  CAS  Google Scholar 

  9. Henquin, J.-C., Dufrane, D., Kerr-Conte, J. & Nequin, M. Am. J. Physiol Endocrin. Metab. 309, 640–650 (2015).

    Article  Google Scholar 

  10. Newgard, C. B. Cell Metab. 25, 43–56 (2017).

    Article  CAS  Google Scholar 

  11. Prentki, M., Matschinsky, F. M. & Madiraju, S. R. Cell Metab. 18, 162–185 (2013).

    Article  CAS  Google Scholar 

  12. Yoshihara, E. et al. Cell Metab. 23, 622–634 (2016).

    Article  CAS  Google Scholar 

  13. Henquin, J.-C. Diabetes Res. Clin. Pract. 93, S27–S31 (2011).

    Article  CAS  Google Scholar 

  14. Ferdaoussi, M. et al. J. Clin. Invest. 125, 3847–3860 (2015).

    Article  Google Scholar 

Download references

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Authors and Affiliations

  1. Sarah W. Stedman Nutrition and Metabolism Center, Duke Molecular Physiology Institute, Department of Pharmacology & Cancer Biology and Department of Medicine, Endocrine Division, Duke University Medical Center, Durham, NC, USA

    Hans E. Hohmeier, Jie An & Christopher B. Newgard

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  1. Hans E. Hohmeier
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  2. Jie An
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  3. Christopher B. Newgard
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Correspondence to Christopher B. Newgard.

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The authors declare no competing interests.

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Hohmeier, H.E., An, J. & Newgard, C.B. Improving human β-cell maturation in vitro. Nat Cell Biol 21, 119–121 (2019). https://doi.org/10.1038/s41556-019-0277-6

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