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PERK links the clock and protein stress in cancer

Nature Cell Biology volume 20, pages 4–5 (2018)Cite this article

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The unfolded protein response (UPR) regulates cell metabolism and survival in response to stress, yet how the UPR is connected to other signalling pathways is poorly understood. PERK is now shown to regulate Bmal1 and Clock proteins to promote cancer cell survival, revealing a link between growth regulation and circadian rhythms.

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Fig. 1: Engagement of the UPR shifts the timing of circadian rhythms.
Fig. 2

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Authors and Affiliations

  1. Centro Nacional de Investigaciones Cardiovasculares, Madrid, Spain

    Miguel Sanchez-Alvarez

  2. Institute of Cancer Research, Chester Beatty Laboratories, London, UK

    Chris Bakal

Authors
  1. Miguel Sanchez-Alvarez
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  2. Chris Bakal
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Correspondence to Chris Bakal.

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Sanchez-Alvarez, M., Bakal, C. PERK links the clock and protein stress in cancer. Nat Cell Biol 20, 4–5 (2018). https://doi.org/10.1038/s41556-017-0019-6

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