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TISSUE REGENERATION

Better growth-factor binding aids tissue repair

Nature Biomedical Engineering volume 4, pages 368–369 (2020)Cite this article

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Enhancing the binding of growth factors to heparan sulfate proteoglycans in the extracellular matrix and on cell surfaces improves wound healing and bone regeneration in mice.

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Fig. 1: Engineering growth factors for tonic signalling.

References

  1. Kim, S., Turnbull, J. E. & Guimond, S. E. J. Endocrinol. 209, 139–151 (2011).

    Article  CAS  Google Scholar 

  2. Mitchell, A., Briquez, P., Hubbell, J. & Cochran, J. Acta Biomaterialia 30, 1–12 (2016).

    Article  CAS  Google Scholar 

  3. Capila, I. & Linhardt, R. Angew. Chem. Int. Ed. 41, 390–412 (2002).

    Article  CAS  Google Scholar 

  4. Mochizuki, M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0469-1 (2019).

    Article  PubMed  Google Scholar 

  5. Martino, M. et al. Science 343, 885–888 (2014).

    Article  CAS  Google Scholar 

  6. Rnjak-Kovacina, J., Tang, F., Whitelock, J. M. & Lord, M. S. Adv. Healthcare Mater. 7, e1701042 (2018).

    Article  Google Scholar 

  7. Freudenberg, U., Liang, Y., Kiick, K. L. & Werner, C. Adv. Mater. 28, 8861–8891 (2016).

    Article  CAS  Google Scholar 

  8. Ayerst, B. I., Merry, C. L. R. & Day, A. J. Pharmaceuticals 10, 54 (2017).

    Article  Google Scholar 

  9. Powell, A. K., Ahmed, Y. A., Yates, E. A. & Turnbull, J. E. Nat. Protoc. 5, 829–841 (2010).

    Article  CAS  Google Scholar 

  10. Taylor, S. L., Hogwood, J., Guo, W., Yates, E. A. & Turnbull, J. E. Sci. Rep. 9, 2679 (2019).

    Article  Google Scholar 

  11. Liu, J. & Linhardt, R. J. Natural Prod. Rep. 31, 1676–1685 (2014).

    Article  CAS  Google Scholar 

  12. Farrugia, B. L., Lord, M. S., Melrose, J. & Whitelock, J. M. Molecules 20, 4254–4276 (2015).

    Article  CAS  Google Scholar 

  13. Lord, M. S. et al. J. Control. Release 250, 48–61 (2017).

    Article  CAS  Google Scholar 

  14. Chen, Y.-H. et al. Nat. Methods 15, 881–888 (2018).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Graduate School of Biomedical Engineering, UNSW Sydney, Sydney, New South Wales, Australia

    Megan Lord & John Whitelock

  2. Wolfson Centre for Stem Cells, Tissue Engineering and Modelling, University of Nottingham, Nottingham, UK

    John Whitelock

  3. Department of Biochemistry, University of Liverpool, Liverpool, UK

    Jeremy E. Turnbull

  4. Copenhagen Center for Glycomics, University of Copenhagen, Copenhagen, Denmark

    Jeremy E. Turnbull

Authors
  1. Megan Lord
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  2. John Whitelock
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  3. Jeremy E. Turnbull
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Corresponding authors

Correspondence to Megan Lord, John Whitelock or Jeremy E. Turnbull.

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Lord, M., Whitelock, J. & Turnbull, J.E. Better growth-factor binding aids tissue repair. Nat Biomed Eng 4, 368–369 (2020). https://doi.org/10.1038/s41551-020-0548-3

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