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COMPUTATIONAL MEDICINE

Affinity-bound antibody–drug conjugates

Nature Biomedical Engineering volume 3, pages 850–851 (2019)Cite this article

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Computationally designed antibody–drug conjugates easily self-assemble via affinity ligands that non-covalently link a therapeutic drug to conserved sites on native IgG antibodies.

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Fig. 1: Affinity linkers for making antibody-drug conjugates.

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Authors and Affiliations

  1. Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT, USA

    Christine S. Nervig & Shawn C. Owen

  2. Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, Salt Lake City, UT, USA

    Shawn C. Owen

Authors
  1. Christine S. Nervig
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  2. Shawn C. Owen
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Correspondence to Shawn C. Owen.

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Nervig, C.S., Owen, S.C. Affinity-bound antibody–drug conjugates. Nat Biomed Eng 3, 850–851 (2019). https://doi.org/10.1038/s41551-019-0478-0

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