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Weakly immunogenic CRISPR therapies

Nature Biomedical Engineering volume 3, pages 761–762 (2019)Cite this article

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Orthologues of CRISPR-associated proteins and of viral vectors evade immune recognition in mice, enabling repeated gene therapy.

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Fig. 1: Potential methods for reducing immune responses to Cas9.

References

  1. Marshall, E. Science 286, 2244–2245 (1999).

    Article  CAS  Google Scholar 

  2. Mingozzi, F. & High, K. A. Blood 122, 23–36 (2013).

    Article  CAS  Google Scholar 

  3. Vandamme, C., Adjali, O. & Mingozzi, F. Hum. Gene Ther. 28, 1061–1074 (2017).

    Article  CAS  Google Scholar 

  4. Wang, D. et al. Hum. Gene Ther. 26, 432–442 (2015).

    Article  CAS  Google Scholar 

  5. Chew, W. L. et al. Nat. Methods 13, 868–874 (2016).

    Article  CAS  Google Scholar 

  6. Simhadri, V. L. et al. Mol. Ther. Methods Clin. Dev. 10, 105–112 (2018).

    Article  CAS  Google Scholar 

  7. Wagner, D. L. et al. Nat. Med. 25, 242–248 (2018).

    Article  Google Scholar 

  8. Ferdosi, S. R. et al. Nat. Commun. 10, 1842 (2019).

    Article  Google Scholar 

  9. Charlesworth, C. T. et al. Nat. Med. 25, 249–254 (2019).

    Article  CAS  Google Scholar 

  10. Moreno, A. M. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0431-2 (2019).

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Authors and Affiliations

  1. Center for Personalized Diagnostics, Biodesign Institute, Arizona State University, Tempe, AZ, USA

    Eric A. Wilson & Karen S. Anderson

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  1. Eric A. Wilson
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  2. Karen S. Anderson
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Correspondence to Karen S. Anderson.

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Competing interests

K.S.A. is noted as an inventor on a patent application regarding Cas9 immunity.

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Wilson, E.A., Anderson, K.S. Weakly immunogenic CRISPR therapies. Nat Biomed Eng 3, 761–762 (2019). https://doi.org/10.1038/s41551-019-0463-7

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