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CANCER DIAGNOSTICS

Enhanced detection of tumour-secreted vesicles

Early-stage ovarian cancer can be detected in few-microlitre plasma samples via a microfluidic chip, patterned with nanoporous herringbone structures so as to enhance the capture of extracellular vesicles from the samples.

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Fig. 1: Detection of ovarian cancer from tumour EVs processed by a microfluidic chip patterned with porous herringbone structures.

References

  1. Torre, L. A. et al. Cancer J. Clin. 68, 284–296 (2018).

    Article  Google Scholar 

  2. Woodward, E. R. et al. Int. J. Gynecol. Obstet. 114, 1500–1509 (2007).

    CAS  Google Scholar 

  3. Becker, A. et al. Cancer Cell 30, 836–848 (2016).

    Article  CAS  Google Scholar 

  4. Siravegna, G., Marsoni, S., Siena, S. & Bardelli, A. Nat. Rev. Clin. Oncol. 14, 531–548 (2017).

    Article  CAS  Google Scholar 

  5. Wan, Y. et al. Nat. Biomed. Eng. 1, 0058 (2017).

    Article  Google Scholar 

  6. Im, H. et al. Nat. Biotechnol. 32, 490–495 (2014).

    Article  CAS  Google Scholar 

  7. Zhang, P. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-019-0356-9 (2019).

  8. Thery, C. Nature 523, 161–162 (2015).

    Article  CAS  Google Scholar 

  9. van Dam, G. M. et al. Nat. Med. 17, 1315–1319 (2011).

    Article  Google Scholar 

  10. Colombo, M., Raposo, G. & Thery, C. Annu. Rev. Cell Dev. Biol. 30, 255–289 (2014).

    Article  CAS  Google Scholar 

  11. EL Andaloussi, S., Mager, I., Breakefield, X. O. & Wood, M. J. Nat. Rev. Drug Discov. 12, 347–357 (2013).

    Article  CAS  Google Scholar 

  12. Wan, Y. et al. Ann. Oncol. 29, 2379–2383 (2018).

    Article  CAS  Google Scholar 

Download references

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Correspondence to Yuan Wan or Si-Yang Zheng.

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Si-Yang Zheng is a founder of Captis Diagnostics.

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Wan, Y., Zheng, SY. Enhanced detection of tumour-secreted vesicles. Nat Biomed Eng 3, 421–422 (2019). https://doi.org/10.1038/s41551-019-0415-2

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