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PHOTOACOUSTIC MICROSCOPY

Imaging intratumoral metabolic heterogeneity

Nature Biomedical Engineering volume 3, pages 333–334 (2019)Cite this article

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The oxygen consumption rates of single tumour cells can be measured via photoacoustic microscopy, by leveraging haemoglobin as both an oxygen supplier and an oxygen sensor.

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Fig. 1: Photoacoustic microscopy quantifies single-cell oxygen consumption in microwell arrays.

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Authors and Affiliations

  1. Morgridge Institute for Research, Madison, WI, USA

    Alex J. Walsh, Joe T. Sharick & Melissa C. Skala

  2. Department of Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, USA

    Melissa C. Skala

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  1. Alex J. Walsh
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  2. Joe T. Sharick
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  3. Melissa C. Skala
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Correspondence to Melissa C. Skala.

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Walsh, A.J., Sharick, J.T. & Skala, M.C. Imaging intratumoral metabolic heterogeneity. Nat Biomed Eng 3, 333–334 (2019). https://doi.org/10.1038/s41551-019-0398-z

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