Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

TISSUE ENGINEERING

A scale model of the human ventricle

A tissue-engineered scale model of the human ventricle made of nanofibrous scaffolds and human-stem-cell-derived cardiomyocytes enables the modelling of arrhythmia.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Fig. 1: Cell-centric and material-centric heart-muscle engineering.

References

  1. Tiburcy, M. et al. Circulation 135, 1832–1847 (2017).

    Article  CAS  Google Scholar 

  2. Ronaldson-Bouchard, K. et al. Nature 556, 239–243 (2018).

    Article  CAS  Google Scholar 

  3. MacQueen, L. A. et al. Nat. Biomed. Eng. https://doi.org/10.1038/s41551-018-0271-5 (2018).

    Article  Google Scholar 

  4. Christoph, J. et al. Nature 555, 667–672 (2018).

    Article  CAS  Google Scholar 

  5. Zhang, B. et al. Nat. Mater. 15, 669–678 (2016).

    Article  CAS  Google Scholar 

  6. Shimizu, T. et al. Circ. Res. 90, e40 (2002).

    Article  CAS  Google Scholar 

  7. Radisic, M., Deen, W., Langer, R. & Vunjak-Novakovic, G. Am. J. Physiol. Heart C 288, H1278–H1289 (2005).

    Article  CAS  Google Scholar 

  8. Gonen-Wadmany, M., Gepstein, L. & Seliktar, D. Ann. NY Acad. Sci. 1015, 299–311 (2004).

    Article  Google Scholar 

  9. Yildirim, Y. et al. Circulation 116, I16–I23 (2007).

    Article  Google Scholar 

  10. Li, R. A. et al. Biomaterials 163, 116–127 (2018).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Wolfram-Hubertus Zimmermann.

Ethics declarations

Competing interests

W.-H.Z. is founder and advisor of Repairon GmbH and myriamed GmbH, which work on the development of engineered heart muscle for heart repair and on the application of engineered tissue for phenotypic drug screens.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zimmermann, WH. A scale model of the human ventricle. Nat Biomed Eng 2, 888–889 (2018). https://doi.org/10.1038/s41551-018-0332-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41551-018-0332-9

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research