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Cancer nanomedicine

Tumour-bound RNA-laden exosomes

Nature Biomedical Engineering volume 1, pages 634–636 (2017)Cite this article

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Exosomes expressing CD47 and loaded with interfering RNA dodge phagocytosis and accumulate in pancreatic tumours to silence the expression of the oncogene Kras in mice, with remarkable therapeutic efficacy.

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Fig. 1: Mechanisms for the accumulation of CD47-expressing exosomes and of synthetic nanoparticles in pancreatic tumour cells.

References

  1. Zeng, L. J. et al. Nanomedicine 10, 463–472 (2014).

    Article  CAS  PubMed  Google Scholar 

  2. Rejiba, S., Wack, S., Aprahamian, M. & Hajri, A. Cancer Sci. 98, 1128–1136 (2007).

    Article  CAS  PubMed  Google Scholar 

  3. Golan, T. et al. Oncotarget 6, 24560–24570 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  4. van der Meel, R. et al. J. Control. Release 195, 72–85 (2014).

    Article  PubMed  Google Scholar 

  5. Kamerkar, S. et al. Nature 546, 498–503 (2017).

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Vader, P., Mol, E. A., Pasterkamp, G. & Schiffelers, R. M. Adv. Drug Del. Rev. 106, 148–156 (2016).

    Article  CAS  Google Scholar 

  7. Lai, C. P. et al. ACS Nano 8, 483–494 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Wiklander, O. P. et al. J. Extracell. Vesicles 4, 26316 (2015).

    Article  PubMed  Google Scholar 

  9. Hoshino, A. et al. Nature 527, 329–335 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Hosotani, R. et al. Pancreas 25, e30–e35 (2002).

    Article  PubMed  Google Scholar 

  11. Commisso, C. et al. Nature 497, 633–637 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Landesman, Y. et al. Silence 1, 16 (2010).

    Article  PubMed  PubMed Central  Google Scholar 

  13. Kooijmans, S. A. et al. J. Control. Release 172, 229–238 (2013).

    Article  CAS  PubMed  Google Scholar 

  14. Lener, T. et al. J. Extracell. Vesicles 4, 30087 (2015).

    Article  PubMed  Google Scholar 

  15. Rodriguez, P. L. et al. Science 339, 971–975 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

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Authors and Affiliations

  1. Laboratory for Clinical Chemistry & Hematology, University Medical Center Utrecht, Utrecht, 3508 TB, The Netherlands

    Sander A. A. Kooijmans, Pieter Vader & Raymond M. Schiffelers

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  1. Sander A. A. Kooijmans
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  2. Pieter Vader
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  3. Raymond M. Schiffelers
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Correspondence to Raymond M. Schiffelers.

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Competing interests

R.M.S. is founder and chief scientific officer of Excytex.

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Kooijmans, S.A.A., Vader, P. & Schiffelers, R.M. Tumour-bound RNA-laden exosomes. Nat Biomed Eng 1, 634–636 (2017). https://doi.org/10.1038/s41551-017-0119-4

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