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Cancer diagnostics: On-target probes for early detection

Nature Biomedical Engineering volume 1, Article number: 0062 (2017) Cite this article

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Optical probes that are activated only in the tumour microenvironment dramatically improve the sensitivity of cancer detection.

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Figure 1: Optimized tumour-activated nanoparticle-based sensors, consisting of a nanoparticle (NP) core decorated with a protease-cleavable substrate and tumour-targeting ligands.
Figure 2: Tumour-activated imaging probe with signal amplification, driven by the conversion of the probe's precursor form into the reporter form.

References

  1. Lutz, A. M. et al. Radiology 259, 329–345 (2011).

    Article  Google Scholar 

  2. Lutz, A. M., Willmann, J. K., Cochran, F. V., Ray, P. & Gambhir, S. S. PLoS Med. 5, e170 (2008).

    Article  Google Scholar 

  3. Hori, S. S. & Gambhir, S. S. Sci. Transl. Med. 3, 109ra116 (2011).

    Article  Google Scholar 

  4. Kwon, E. J., Dudani, J. S. & Bhatia, S. N. Nat. Biomed. Eng. 1, 0054 (2017).

    Article  Google Scholar 

  5. Zheng, X. et al. Nat. Biomed. Eng. 1, 0057 (2017).

    Article  Google Scholar 

  6. Kwong, G. A. et al. Proc. Natl Acad. Sci. USA 112, 12627–12632 (2015).

    Article  CAS  Google Scholar 

  7. Kwong, G. A. et al. Nat. Biotechnol. 31, 63–70 (2013).

    Article  CAS  Google Scholar 

  8. Whitley, M. J. et al. Sci. Transl. Med. 8, 320ra324 (2016).

    Article  Google Scholar 

  9. Ronald, J. A., Chuang, H. Y., Dragulescu-Andrasi, A., Hori, S. S. & Gambhir, S. S. Proc. Natl Acad. Sci. USA 112, 3068–3073 (2015).

    Article  CAS  Google Scholar 

  10. Wang, Y. et al. Nat. Mater. 13, 204–212 (2014).

    Article  CAS  Google Scholar 

  11. Jiang, T. et al. Proc. Natl Acad. Sci. USA 101, 17867–17872 (2004).

    Article  CAS  Google Scholar 

  12. Urano, Y. et al. Nat. Med. 15, 104–109 (2009).

    Article  CAS  Google Scholar 

  13. Zheng, X. et al. Nat. Commun. 6, 5834 (2015).

    Article  CAS  Google Scholar 

  14. Webb, B. A., Chimenti, M., Jacobson, M. P. & Barber, D. L. Nat. Rev. Cancer 11, 671–677 (2011).

    Article  CAS  Google Scholar 

  15. Gilkes, D. M., Semenza, G. L. & Wirtz, D. Nat. Rev. Cancer 14, 430–439 (2014).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Willemieke S. Tummers and Sanjiv S. Gambhir are in the Department of Radiology, Sharon S. Hori, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.,

    Sharon S. Hori, Willemieke S. Tummers & Sanjiv S. Gambhir

  2. Sanjiv S. Gambhir is also in the Departments of Bioengineering, and Materials Science and Engineering, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.,

    Sanjiv S. Gambhir

Authors
  1. Sharon S. Hori
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  2. Willemieke S. Tummers
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  3. Sanjiv S. Gambhir
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Correspondence to Sanjiv S. Gambhir.

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Hori, S., Tummers, W. & Gambhir, S. Cancer diagnostics: On-target probes for early detection. Nat Biomed Eng 1, 0062 (2017). https://doi.org/10.1038/s41551-017-0062

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