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Cancer diagnostics: On-target probes for early detection

Optical probes that are activated only in the tumour microenvironment dramatically improve the sensitivity of cancer detection.

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References

  1. 1.

    et al. Radiology 259, 329–345 (2011).

  2. 2.

    , , , & PLoS Med. 5, e170 (2008).

  3. 3.

    & Sci. Transl. Med. 3, 109ra116 (2011).

  4. 4.

    , & Nat. Biomed. Eng. 1, 0054 (2017).

  5. 5.

    et al. Nat. Biomed. Eng. 1, 0057 (2017).

  6. 6.

    et al. Proc. Natl Acad. Sci. USA 112, 12627–12632 (2015).

  7. 7.

    et al. Nat. Biotechnol. 31, 63–70 (2013).

  8. 8.

    et al. Sci. Transl. Med. 8, 320ra324 (2016).

  9. 9.

    , , , & Proc. Natl Acad. Sci. USA 112, 3068–3073 (2015).

  10. 10.

    et al. Nat. Mater. 13, 204–212 (2014).

  11. 11.

    et al. Proc. Natl Acad. Sci. USA 101, 17867–17872 (2004).

  12. 12.

    et al. Nat. Med. 15, 104–109 (2009).

  13. 13.

    et al. Nat. Commun. 6, 5834 (2015).

  14. 14.

    , , & Nat. Rev. Cancer 11, 671–677 (2011).

  15. 15.

    , & Nat. Rev. Cancer 14, 430–439 (2014).

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Author information

Affiliations

  1. Sharon S. Hori, Willemieke S. Tummers and Sanjiv S. Gambhir are in the Department of Radiology, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.

    • Sharon S. Hori
    • , Willemieke S. Tummers
    •  & Sanjiv S. Gambhir
  2. Sanjiv S. Gambhir is also in the Departments of Bioengineering, and Materials Science and Engineering, Stanford University, 318 Campus Drive, Stanford, California 94305, USA.

    • Sanjiv S. Gambhir

Authors

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Corresponding author

Correspondence to Sanjiv S. Gambhir.