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Image-guided surgery: Transistor-like pH nanoprobes

Nature Biomedical Engineering volume 1, Article number: 0018 (2017) Cite this article

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Nanoprobes that fluoresce only when activated by the acidic environment in tumours may make a universal imaging agent for cancer surgery.

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Figure 1: Optimal pre-clinical assessment of fluorescence agents for tumour imaging.
Figure 2: Radioisotope imaging (FDG–PET), and intraoperative imaging with white light and pH-sensitive, near-infrared fluorescent nanoprobes in severe-combined-immunodeficiency mice bearing large (top row) and small (bottom row) head-and-neck tumours.

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Authors and Affiliations

  1. Nynke S. van den Berg and Eben L. Rosenthal are in the Department of Otolaryngology — Head and Neck Surgery, Stanford University, Stanford, California 94305, USA.,

    Nynke S. van den Berg & Eben L. Rosenthal

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  1. Nynke S. van den Berg
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  2. Eben L. Rosenthal
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Correspondence to Eben L. Rosenthal.

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van den Berg, N., Rosenthal, E. Image-guided surgery: Transistor-like pH nanoprobes. Nat Biomed Eng 1, 0018 (2017). https://doi.org/10.1038/s41551-016-0018

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