Figure 4: Nature Communications

Fig. 4

From: Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc

Fig. 4

Overall structure of Prc. a Domain organization of Prc. NHD and CHD denote the Prc-specific N- and C-terminal helical domains, respectively. NID denotes NlpI-interaction domain. b Two orthogonal views of Prc. Only one of the two Prc molecules (chain C) in the structure is shown. c A zoomed-in view of the co-crystallized peptide bound to the PDZ domain and interacting with hydrophobic residues at the hinge. The peptide bound to chain C is modeled as the MepS C-terminal tetrapeptide LSRS-COOH, of which the penultimate residue (R-1) forms a hydrogen bond with D342