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Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension

Hypertension Research volume 43, pages 1284–1292 (2020)Cite this article

Abstract

The score based on the office systolic blood pressure, age, fasting blood glucose level, and estimated glomerular filtration rate (SAGE score) has been proposed as a useful marker to identify elevated values of carotid-femoral pulse wave velocity (PWV). The present cross-sectional study was conducted to examine whether the SAGE score is also a useful marker to identify subjects with elevated brachial-ankle PWV values in Japanese subjects with hypertension. We measured the brachial-ankle PWV and calculated the SAGE score in a total of 1019 employees of a Japanese company with hypertension and 817 subjects with hypertension derived from a multicenter study cohort. The analyses in this study were based on data from these two study groups as well as on a composite population of the two (n = 1836). The receiver operating characteristic curve analysis showed that the area under the curve to identify subjects with brachial-ankle PWV values of ≥1800 cm/s was over 0.70 in each of the three study groups. Even after adjustments, a SAGE score ≥7 had a significant odds ratio for identifying subjects with brachial-ankle PWV values ≥1800 cm/s in the 1836 study subjects from the composite occupational and multicenter study cohort (odds ratio = 2.1, 95% confidence interval = 1.4–3.0, P < 0.01). Thus, in Japanese subjects with hypertension, the SAGE score may be a useful marker for identifying subjects with elevated brachial-ankle PWV values.

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Funding

This study was partially supported financially by a Grant-in-Aid for scientific research from the Ministry of Health, Labour and Welfare, by the Japanese Atherosclerosis Prevention Research Fund (A study of Multi-center Assessment on the Clinical Usefulness of Semi-automatic Measurement of Flow-mediated Vasodilatation of the Brachial Artery: FMD-J study), and by the Omron Health Care Company, Kyoto, Japan.

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Authors and Affiliations

  1. Department of Cardiology, Tokyo Medical University, Tokyo, Japan

    Hirofumi Tomiyama, Hiroki Nakano, Kazuki Shiina, Taishiro Chikamori & Akira Yamashina

  2. Hypertension and Cardiometabolic Unit, (1st) Department of Cardiology, National and Kapodistrian University of Athens, Hippokration Hospital, Athens, Cyprus

    Charalambos Vlachopoulos & Panagiotis Xaplanteris

  3. Cardiology Department, CHU Saint-Pierre, Université Libre de Bruxelles, 322 rue Haute, B-1000, Brussels, Belgium

    Panagiotis Xaplanteris

  4. Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan

    Tomoko Ishizu

  5. Department of Clinical Informatics, Jichi Medical University School of Medicine, Tochigi, Japan

    Takahide Kohro

  6. Department of Cardiovascular Physiology and Medicine, Hiroshima University Graduate School of Biomedical Science, Hiroshima, Japan

    Yukihito Higashi

  7. Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama, Japan

    Bonpei Takase

  8. Cardiovascular Medicine, University of Leicester, Leicester, UK

    Toru Suzuki

  9. Department of Clinical Epidemiology and Systems, Faculty of Medicine, The University of Tokyo, Tokyo, Japan

    Tsutomu Yamazaki

  10. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Hokkaido, Japan

    Tomoo Furumoto

  11. Division of Cardiovascular Medicine, Jichi Medical University School of Medicine, Tochigi, Japan

    Kazuomi Kario

  12. Department of Cardiovascular Medicine, Dokkyo Medical University, Mibu, Tochigi, Japan

    Teruo Inoue

  13. Department of Medicine, Division of Cardiology, Showa University School of Medicine, Tokyo, Japan

    Shinji Koba

  14. Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine, Osaka, Japan

    Yasuhiko Takemoto

  15. Department of Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University, Wakayama, Japan

    Takuzo Hano

  16. Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

    Masataka Sata

  17. Department of General Medicine, Shimane University Faculty of Medicine, Izumo, Japan

    Yutaka Ishibashi

  18. Department of Cardiovascular and Renal Medicine, Saga University, Saga, Japan

    Koichi Node & Atsushi Tanaka

  19. Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan

    Koji Maemura

  20. The Third Department of Internal Medicine, University of the Ryukyus, Okinawa, Japan

    Yusuke Ohya

  21. Department of Internal Medicine, Teikyo University School of Medicine, Tokyo, Japan

    Taiji Furukawa

  22. Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okinawa, Japan

    Hiroshi Ito

  23. Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Toshiaki Ohkuma

  24. Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Toshiharu Ninomiya

  25. Department of Clinical Pharmacology and Therapeutics, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan

    Shin-ichiro Ueda

Authors
  1. Hirofumi Tomiyama
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  2. Charalambos Vlachopoulos
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  21. Atsushi Tanaka
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  27. Toshiharu Ninomiya
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  28. Taishiro Chikamori
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  29. Akira Yamashina
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  30. Shin-ichiro Ueda
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Corresponding authors

Correspondence to Hirofumi Tomiyama or Shin-ichiro Ueda.

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Conflict of interest

The sponsor (Omron Health Care Company) assisted in the data formatting (i.e., the brachial-ankle pulse wave velocity data stored in the hard disc of the equipment used for measurement of the brachial-ankle pulse wave velocity was transferred to an Excel file); other than this, the company played no role in the design or conduct of the study, i.e., in the data collection, management, analysis or interpretation of the data, or in the preparation, review or approval of the manuscript.

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Tomiyama, H., Vlachopoulos, C., Xaplanteris, P. et al. Usefulness of the SAGE score to predict elevated values of brachial-ankle pulse wave velocity in Japanese subjects with hypertension. Hypertens Res 43, 1284–1292 (2020). https://doi.org/10.1038/s41440-020-0472-7

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