Currently, high blood pressure (BP) may cover different hypertension phenotypes, including white coat hypertension (WCHT), masked hypertension (MHT), and sustained hypertension (SHT), all of which are characterized by substantially higher risk of cardiovascular (CV) events and mortality than normotension (NT) [1,2,3,4,5]. This has recently been reaffirmed by the latest sets of European guidelines [6], which emphasized the role of out-of-office BP assessment, such as 24-h ambulatory and home BP monitoring, to properly stratify apparently low-risk individuals with high-normal BP levels. The same guidelines also recommended that a search for hypertension-mediated organ damage or other risk factors and comorbidities should be performed in patients with WCHT or MHT, in view of the relative frequency of these risk factors and markers of organ damage in these hypertensive patients [6].
Despite this evidence, both WCHT and MHT are often undiagnosed or even untreated. Findings from large national databases or clinical studies have clearly demonstrated that both of these conditions are relatively common in the clinical practice of hypertension [7]. Other studies have also reported that, even in the presence of antihypertensive treatment, effective BP control is not achieved in patients with WCHT or MHT, with obvious and relevant consequences on the risk of developing major CV outcomes [8,9,10].
Sustained BP elevation still represents the major contributing factor for the occurrence of coronary events, including acute coronary syndrome, myocardial infarction, coronary revascularization, and death due to coronary disease [11]. Thus, it can be argued that early identification of patients with uncontrolled BP levels and asymptomatic coronary artery disease might improve CV disease prevention and reduce the burden of hypertension-related CV morbidity and mortality.
In this issue of Hypertension Research, Wang and coworkers present an analysis of a relatively large database of adult hypertensive outpatients with symptoms of angina and electrocardiographic changes of myocardial ischemia, who were stratified in the four hypertension phenotypes. All patients underwent coronary angiography and conventional electrocardiogram to assess the presence of coronary artery stenosis or cardiac arrhythmias, respectively. In this population, the prevalence of MHT was remarkably higher than, while the prevalence of WCHT was similar to, that reported in previous clinical studies performed in different clinical settings, as schematically shown in Fig. 1 [1,2,3,4,5].
The prevalence of different hypertension phenotypes may be affected by several factors, such as BP thresholds, inclusion/exclusion criteria for the reference population, and the reproducibility of BP assessments over time [12, 13]. In the study performed by Wang, the observed high prevalence of MHT can be explained by the very high-risk profile of patients with the signs or symptoms of myocardial ischemia. On the other hand, the observed prevalence of MHT can also be conditioned by the BP thresholds used for the definitions of the different hypertension phenotypes. Indeed, Wang and coworkers adopted clinic and all ambulatory (24-h, day-time and night-time) BP thresholds for identifying WCHT and MHT, while other authors used the combination of clinic and either home or 24-h ambulatory BP levels.
Beyond these considerations, all these studies agreed on the fact that both WCHT and MHT are associated with a higher risk of CV outcomes than NT [1,2,3,4,5]. Of note, in the study by Wang and coworkers, the incidence of coronary artery disease in both the MHT and SHT groups were significantly higher than that in the NT group, but there was no significant difference between the WCHT and the NT groups, thus highlighting that neither of these conditions should be considered an innocent report.
In conclusion, based on the available evidence, integrated clinical risk assessment should be adopted in patients with either WCHT or MHT to prevent the occurrence of major CV events, mostly coronary artery disease.
Early recognition of these individuals is a key element for adopting preventive strategies aimed at reducing their CV risk profile, as also highlighted by current European guidelines [6]. Thus, more widespread use of out-of-office BP measurements might also be recommended in the general population [6], with the aim of identifying those patients with WCHT or MHT before the development of SHT or the occurrence of major CV outcomes.
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Tocci, G., Presta, V. White-coat and masked hypertension and coronary artery disease: are they related or not?. Hypertens Res 43, 151–152 (2020). https://doi.org/10.1038/s41440-019-0368-6
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DOI: https://doi.org/10.1038/s41440-019-0368-6