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A novel indicator, childhood lipid accumulation product, is associated with hypertension in Chinese children and adolescents

Hypertension Research volume 43, pages 305–312 (2020)Cite this article

Abstract

Childhood hypertension has become an important public health issue. This study explored a novel indicator, namely, childhood lipid accumulation product (CLAP), which is associated with hypertension among children and adolescents. A total of 683 children and adolescents aged 8–15 years were measured for body weight, height, waist circumference (WC), abdominal skinfold thickness (AST), triacylglycerol (TG), blood pressure, dietary behaviors, and physical activity time. The novel childhood lipid accumulation product (CLAP) was the product of WC, AST, and TG (CLAP = WC (cm) × AST (mm) × TG (mmol/L)). The logarithmic CLAP (LnCLAP), height, weight, WC, WHtR, BMI, AST, and TG were standardized for sex and age using the z-score method (standardized variables: SLnCLAP, Sheight, Sweight, SWC, SWHtR, SBMI, SAST, and STG). The results showed that the overall prevalence of hypertension was 11.6% (13.1% in boys and 9.7% in girls). SLnCLAP ≥ 1, Sweight ≥ 1, SWC ≥ 1, SWHtR ≥ 1, SBMI ≥ 1, SAST ≥ 1, and STG ≥ 1 increased the statistical risk of childhood hypertension (odds ratio values (95% CI) were 3.70 (2.22–6.16), 2.58 (1.50–4.43), 3.08 (1.84–5.15), 2.33 (1.38–3.93), 2.96 (1.72–5.29), 2.38 (1.41–4.70), and 2.40 (1.38–4.19), respectively). The area under the ROC curve (AUC) for CLAP was higher than that for weight, WC, WHtR, BMI, AST, and TG in the prediction of hypertension. In conclusion, this study showed that CLAP is a novel indicator associated with hypertension in children and adolescents and can more effectively predict childhood hypertension than weight, WC, WHtR, BMI, AST, and TG can.

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Acknowledgements

The authors would like to thank the students who participated in the present study, as well as Weige Jiang and Yu Liu for their assistance in recruiting students.

Funding

This work was supported by the National Natural Science Foundation of China (81502823), the Outstanding Young Talent Key program of colleges and universities in Anhui Province (gxyqZD2017063), and Bengbu Medical College Scientific and Innovation Research for Graduate Students (Byycx1854).

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  1. These authors contributed equally: Yuan Wang, Wenmin Liu

Authors and Affiliations

  1. Department of Child and Adolescent Health, School of Public Health, Bengbu Medical College, Bengbu, 233000, Anhui, PR China

    Yuan Wang, Wenmin Liu, Lili Sun, Yifei Zhang, Bangxuan Wang, Yongting Yuan, Ting Li, Rongying Yao, Hui Han & Lianguo Fu

  2. Bengbu Centers for Disease Control and Prevention, Bengbu, 233000, Anhui, PR China

    Qingwen Qian

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Contributions

YW and WL collected and analyzed the data and prepared the first draft of the manuscript. LS and YZ analyzed and collected the data. BW, YY, TL, RY, and HH collected the data. QQ revised the manuscript. LF conceived and designed the research and revised the manuscript.

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Correspondence to Lianguo Fu.

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The Ethics Committee of the Bengbu Medical College ([2015] No. 003) approved the study.

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Wang, Y., Liu, W., Sun, L. et al. A novel indicator, childhood lipid accumulation product, is associated with hypertension in Chinese children and adolescents. Hypertens Res 43, 305–312 (2020). https://doi.org/10.1038/s41440-019-0366-8

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