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Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case–control studies

Genes & Immunity volume 20, pages 484–492 (2019)Cite this article

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Abstract

Emerging evidence revealed that thyroglobulin (TG) contributes to the development of autoimmune disease, and the relationship between TG and autoimmune thyroid disease (AITD) is still controversial. The aim of this study was to quantify the association between rs2076740, rs853326, rs180223, and rs2069550 TG polymorphisms and risk of AITD using a meta-analysis approach. We identified all studies that assessed the association between TG polymorphisms and AITD from PubMed, Embase, and Web of Science databases. A total of 3013 cases and 1812 controls from ten case–control studies were included. There was no significant associations found between rs2069550, rs180223, and rs853326 polymorphisms and AITD risk. The association between the rs2076740 polymorphism and AITD risk was significant in the codominant model (P = 0.005), suggesting the CC rs2076740 genotype might be a protective factor for AITD. Sensitivity analysis by removing one or two study changed the results in dominant rs2076740 and rs853326 and rs2069550 allele models (P = 0.016, 0.024, 0.027). Latitude and ethnicity significantly affected the association between rs2076740 and rs2069550 polymorphisms and AITD, indicating their protective effects in allele or dominant model (P = 0.012, 0.012, 0.012, 0.009, 0.009). The association between rs2076740, rs2069550, and rs853326 polymorphisms and AITD risk is significantly affected by study characteristics.

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Acknowledgements

This study was supported by the National Natural Science Foundation of China (no. 31570357).

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Authors and Affiliations

  1. Department of Pharmacy, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang; The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, Henan, China

    Ming-Liang Zhang & Cai-E. Wang

  2. Department of Endocrinology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China

    Dong-ming Zhang

  3. Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China

    Xiao-Long Chen

  4. Henan Province Chinese Medicine Research Institute, Zhengzhou, Henan, China

    Fang-Zhou Liu

  5. Department of Neurology, The First Affiliated Hospital and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China

    Jian-Xue Yang

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Correspondence to Jian-Xue Yang.

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Zhang, ML., Zhang, Dm., Wang, CE. et al. Association between thyroglobulin polymorphisms and autoimmune thyroid disease: a systematic review and meta-analysis of case–control studies. Genes Immun 20, 484–492 (2019). https://doi.org/10.1038/s41435-018-0042-z

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