Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Brief Communication
  • Published:

Association between intraoperative magnesium sulfate infusion and mortality after non-cardiac surgery: a retrospective propensity score matched analysis

European Journal of Clinical Nutrition volume 73, pages 483–486 (2019)Cite this article

Subjects

Abstract

The short-term effects of magnesium sulfate infusion during surgery are well known. However, the long-term outcomes of intraoperative magnesium sulfate infusion remain unknown. Medical records of patients aged ≥20 years who underwent non-cardiac surgical procedures at Seoul National University Bundang Hospital between January, 2010 and October, 2016 were analyzed. After propensity score matching, 12,652 patients were included in the final analysis, 6326 each in the magnesium and non-magnesium groups. There were no significant differences in 30-day or 1-year mortality between subjects [30-day mortality, hazard ratio (HR): 1.31, 95% CI: 0.64–2.69, P = 0.465; 1-year mortality, HR: 1.20, 95%CI: 0.94–1.53, P = 0.136]. Intraoperative magnesium sulfate infusion was not significantly associated with postoperative 30-day or 1-year mortality.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Guasch-Ferre M, Bullo M, Estruch R, Corella D, Martinez-Gonzalez MA, Ros E, et al. Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk. J Nutr. 2014;144:55–60. https://doi.org/10.3945/jn.113.183012.

    Article  CAS  PubMed  Google Scholar 

  2. You S, Zhong C, Du H, Zhang Y, Zheng D, Wang X, et al. Admission low magnesium level is associated with in-hospital mortality in acute ischemic stroke patients. Cerebrovasc Dis. 2017;44:35–42. https://doi.org/10.1159/000471858.

    Article  CAS  PubMed  Google Scholar 

  3. Schmaderer C, Braunisch MC, Suttmann Y, Lorenz G, Pham D, Haller B, et al. Reduced mortality in maintenance haemodialysis patients on high versus low dialysate magnesium: a pilot study. Nutrients. 2017;9:E926. https://doi.org/10.3390/nu9090926.

  4. Yu L, Li H, Wang SX. Serum magnesium and mortality in maintenance hemodialysis patients. Blood Purif. 2017;43:31–6. https://doi.org/10.1159/000451052.

    Article  CAS  PubMed  Google Scholar 

  5. Rubenowitz E, Molin I, Axelsson G, Rylander R. Magnesium in drinking water in relation to morbidity and mortality from acute myocardial infarction. Epidemiology. 2000;11:416–21.

    Article  CAS  Google Scholar 

  6. Kaluza J, Orsini N, Levitan EB, Brzozowska A, Roszkowski W, Wolk A. Dietary calcium and magnesium intake and mortality: a prospective study of men. Am J Epidemiol. 2010;171:801–7. https://doi.org/10.1093/aje/kwp467.

    Article  PubMed  Google Scholar 

  7. Hirashima J, Yamana H, Matsui H, Fushimi K, Yasunaga H. Effect of intravenous magnesium sulfate on mortality in patients with severe acute asthma. Respirology. 2016;21:668–73. https://doi.org/10.1111/resp.12733.

    Article  PubMed  Google Scholar 

  8. Naksuk N, Hu T, Krittanawong C, Thongprayoon C, Sharma S, Park JY, et al. Association of serum magnesium on mortality in patients admitted to the intensive cardiac care unit. Am J Med. 2017;130:229.e5–13. https://doi.org/10.1016/j.amjmed.2016.08.033.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Anesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam-si, South Korea

    Tak Kyu Oh & Sang-Hwan Do

  2. Medical Research Collaborating Center, Seoul National University Bundang Hospital, Seongnam-si, South Korea

    Eunjeong Ji

Authors
  1. Tak Kyu Oh
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eunjeong Ji
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sang-Hwan Do
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

T.K.O. designed the study and drafted the manuscript; E.J. contributed to the acquisition of data and analyzed the data; S.-H.D. contributed to the interpretation of data and provided critical revisions of the manuscript. All authors have given final approval for the final version of the manuscript.

Corresponding author

Correspondence to Sang-Hwan Do.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Oh, T.K., Ji, E. & Do, SH. Association between intraoperative magnesium sulfate infusion and mortality after non-cardiac surgery: a retrospective propensity score matched analysis. Eur J Clin Nutr 73, 483–486 (2019). https://doi.org/10.1038/s41430-018-0332-6

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41430-018-0332-6

Search

Advanced search

Quick links