Abstract
Iseolides A–C (1–3), three new glycosylated macrolides, were identified from the culture extract of Streptomyces sp. DC4-5 isolated from a stony coral Dendrophyllia. Extensive analysis of one- and two-dimensional NMR data, coupled with MS/MS analytical data, revealed that iseolides are new congeners of 36-membered macrolides, PM100117 and PM100118, previously reported from a marine-derived Streptomyces. Iseolides showed potent antifungal activity against a plant pathogen Glomerella cingulata and human pathogens Candida albicans and Trichophyton rubrum with MIC in the range of 0.19–6.25 μg/mL.
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Acknowledgements
Authors are in debt to Prof. Yasufumi Hikichi and Dr Ayami Kanda at Kochi University for providing R. solanacearum SUPP1541. P388 cells were obtained from JCRB Cell Bank under an accession code JCRB0017 (Lot. 06252002).
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Dedicated to Professor William Fenical in recognition of his pioneering and outstanding contributions to marine natural products.
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Zhang, Z., Zhou, T., Harunari, E. et al. Iseolides A–C, antifungal macrolides from a coral-derived actinomycete of the genus Streptomyces. J Antibiot 73, 534–541 (2020). https://doi.org/10.1038/s41429-020-0304-7
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DOI: https://doi.org/10.1038/s41429-020-0304-7
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