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Identification of novel in vitro antibacterial action of cloprostenol and evaluation of other non-antibiotics against multi-drug resistant A. baumannii

The Journal of Antibiotics volume 73, pages 72–75 (2020)Cite this article

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Abstract

A total of 24 non-antibiotic compounds were tested for their antimicrobial activity against Escherichia coli, Klebsiella pneumoniae (ATCC) and an MDR strain of Acinetobacter baumannii using an agar well diffusion assay. To study additive effects, 100 µl of each antibiotic and 50 µl of each non-antibiotic were used. Cloprostenol was the only non-antibiotic that showed antibacterial activity against all bacterial strains. Cloprostenol had an additive antimicrobial effect with the tested antibiotics against the MDR A. baumannii strain.

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Authors and Affiliations

  1. Institute of Microbiology, University of Agriculture Faisalabad, Faisalabad, 38040, Punjab, Pakistan

    Shakeel Shahzad

  2. School of Optometry and Vision Science, Member of Equity, University of New South Wales Sydney, Sydney, NSW, 2052, Australia

    Mark Willcox

  3. Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Punjab, Pakistan

    Aqeel Shahzad

Authors
  1. Shakeel Shahzad
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  2. Mark Willcox
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  3. Aqeel Shahzad
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Contributions

SS involved in the basic concept and design of study and flow up with experiments; also involved in the evaluation of results and data analysis; involved in drafting of article from initial stage. MW involved in the final data assessment in figures; involved in critical revision; also involved in the final approval of the manuscript. AS involved in the study design materials and methods; involved in the critical revision of the manuscript.

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Correspondence to Shakeel Shahzad.

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Shahzad, S., Willcox, M. & Shahzad, A. Identification of novel in vitro antibacterial action of cloprostenol and evaluation of other non-antibiotics against multi-drug resistant A. baumannii. J Antibiot 73, 72–75 (2020). https://doi.org/10.1038/s41429-019-0244-2

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