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Induced terreins production from marine red algal-derived endophytic fungus Aspergillus terreus EN-539 co-cultured with symbiotic fungus Paecilomyces lilacinus EN-531

The Journal of Antibiotics volume 73, pages 108–111 (2020)Cite this article

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Abstract

The coculture of marine red algal-derived endophytic fungi Aspergillus terreus EN-539 and Paecilomyces lilacinus EN-531 induced the production of a new terrein derivative, namely asperterrein (1) and a known dihydroterrein (2), which were not detected in the axenic cultures of both strains. The production of the known secondary metabolites terrein (3), butyrolactone I (4), and dankasterone (6), derived from A. terreus EN-539, were depressed significantly in the coculture. Compounds 1–3 exhibited inhibitory activity against Alternaria brassicae, Escherichia coli, Physalospora piricola, and Staphylococcus aureus with MIC values ranging from 4 to 64 μg ml−1.

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Acknowledgements

This work was financially supported by the National Natural Science Foundation of China (31330009). H-LL thanks the Natural Science Foundation of Shandong Province (ZR2018BD031) and China Postdoctoral Science Foundation (2018M632732) for the support. B-GW appreciates the support of Taishan Scholar Program from Shandong Province.

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Authors and Affiliations

  1. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Laboratory of Marine Biology and Biotechnology, Qingdao National Laboratory for Marine Science and Technology, Nanhai Road 7, Qingdao, China

    Hong-Lei Li, Xiao-Ming Li, Sui-Qun Yang, Jin Cao, Yan-He Li & Bin-Gui Wang

  2. Center for Ocean Mega-Science, Chinese Academy of Sciences, Nanhai Road 7, Qingdao, China

    Hong-Lei Li, Xiao-Ming Li, Sui-Qun Yang & Bin-Gui Wang

  3. University of Chinese Academy of Sciences, Yuquan Road 19A, Beijing, China

    Jin Cao & Yan-He Li

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  1. Hong-Lei Li
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Correspondence to Bin-Gui Wang.

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Li, HL., Li, XM., Yang, SQ. et al. Induced terreins production from marine red algal-derived endophytic fungus Aspergillus terreus EN-539 co-cultured with symbiotic fungus Paecilomyces lilacinus EN-531. J Antibiot 73, 108–111 (2020). https://doi.org/10.1038/s41429-019-0242-4

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