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Data availability
The datasets used and/or analyzed during the current study are available from the corresponding authors on reasonable request.
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Acknowledgements
We thank all the patients and their family and the healthy volunteers for participating in the present study. We thank Long Ma, Wei-nian Shou, and Wen-jun Zhang for critical reading of the paper. This study was supported by the National Natural Science Foundation of China (81770002 to HL, 81470445 to Z-p.T., 81900002 to T.G., and 81570288 to Y-f.Y.), the Planned Science and Technology Project of Hunan Province, China (2015JC3032 to Y-f.Y.), the Science and Technology Program of Changsha, China (kq1901120 to H.L.), and the National Key Clinical Specialty Construction Projects of China.
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Conceived and designed the experiments: H.L. and Z-p.T. Performed the experiments: D-h.Y., T.G., and Z-z.Y., Collected samples: D-h.Y., T.G., and S-z.D. Analyzed the data: Z-p.T., H.L., D-h.Y., T.G., and Y-f.Y. Wrote the text of the main paper: D-h.Y., Z-p.T., and H.L. Prepared the figures: D-h.Y. and L.C. All authors reviewed and revised the paper.
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The authors declare no competing interests.
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The present study was approved by the Ethics Committee of the Second Xiangya Hospital, Central South University (Changsha, China).
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Written informed consent was obtained from the patient and his parents for publication.
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Yang, Dh., Guo, T., Yuan, Zz. et al. Mutant CARD10 in a family with progressive immunodeficiency and autoimmunity. Cell Mol Immunol 17, 782–784 (2020). https://doi.org/10.1038/s41423-020-0423-x
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DOI: https://doi.org/10.1038/s41423-020-0423-x