Curado, M et al. Cancer Incidence In Five Continents. (IARC Press, Lyon, 2007). .
Miller, K. D. et al. Cancer treatment and survivorship statistics, 2016. CA Cancer J. Clin.
66, 271–289 (2016).
Feldman, D. R., Bosl, G. J., Sheinfeld, J. & Motzer, R. J. Medical treatment of advanced testicular cancer. JAMA
299, 672–684 (2008).
Haugnes, H. S. et al. Long-term and late effects of germ cell testicular cancer treatment and implications for follow-up. J. Clin. Oncol.
30, 3752–3763 (2012).
Christensen, J. F., Bandak, M., Campbell, A., Jones, L. W. & Hojman, P. Treatment-related cardiovascular late effects and exercise training countermeasures in testicular germ cell cancer survivorship. Acta Oncol.
54, 592–599 (2015).
Sprauten, M. et al. Chronic fatigue in 812 testicular cancer survivors during long-term follow-up: increasing prevalence and risk factors. Ann. Oncol.
26, 2133–2140 (2015).
Dahl, A. A. et al. Study of anxiety disorder and depression in long-term survivors of testicular cancer. J. Clin. Oncol.
23, 2389–2395 (2005).
Smith, A. B. et al. The prevalence, severity, and correlates of psychological distress and impaired health-related quality of life following treatment for testicular cancer: a survivorship study. J. Cancer Surviv
10, 223–233 (2016).
Mock, V. et al. NCCN practice guidelines for cancer-related fatigue. Oncology
14, 151–161 (2000).
Orre, I. J. et al. Chronic cancer-related fatigue in long-term survivors of testicular cancer. J. Psychosom. Res
64, 363–371 (2008).
Oechsle, K. et al. Symptom burden in long-term germ cell tumour survivors. Support Care Cancer
24, 2243–2250 (2016).
Mustian, K. M. et al. Comparison of pharmaceutical, psychological, and exercise treatments for cancer-related fatigue: a meta-analysis. JAMA Oncol.
3, 961–968 (2017).
Brown, J. C. et al. The efficacy of exercise in reducing depressive symptoms among cancer survivors: a meta-analysis. PloS ONE
7, e30955 (2012).
Mishra, S. I., Scherer, R. W., Snyder, C., Geigle, P. & Gotay, C. Are exercise programs effective for improving health-related quality of life among cancer survivors? A systematic review and meta-analysis. Oncol. Nurs. Forum
41, E326–E342 (2014).
Thorsen, L. et al. The association between self-reported physical activity and prevalence of depression and anxiety disorder in long-term survivors of testicular cancer and men in a general population sample. Support Care Cancer
13, 637–646 (2005).
Fung, C. et al. Multi-institutional assessment of adverse health outcomes among North American testicular cancer survivors after modern cisplatin-based chemotherapy. J. Clin. Oncol.
35, 1211–1222 (2017).
Adams, S. C. et al. Effects of high-intensity aerobic interval training on cardiovascular disease risk in testicular cancer survivors: a phase II randomised controlled trial. Cancer
123, 4057–4065 (2017).
Courneya, K. S. et al. Randomised controlled trial of exercise training in postmenopausal breast cancer survivors: Cardiopulmonary and quality of life outcomes. J. Clin. Oncol.
21, 1660–1668 (2003).
Buffart, L. M. et al. Fatigue mediates the relationship between physical fitness and quality of life in cancer survivors. J. Sci. Med Sport
16, 99–104 (2013).
Courneya, K. S. et al. Randomised controlled trial of the effects of aerobic exercise on physical functioning and quality of life in lymphoma patients. J. Clin. Oncol.
27, 4605–4612 (2009).
Rognmo, O., Hetland, E., Helgerud, J., Hoff, J. & Slordahl, S. A. High intensity aerobic interval exercise is superior to moderate intensity exercise for increasing aerobic capacity in patients with coronary artery disease. Eur. J. Cardiovasc Prev. Rehabil.
11, 216–222 (2004).
Mezzani, A. et al. Aerobic exercise intensity assessment and prescription in cardiac rehabilitation: a joint position statement of the European Association for Cardiovascular Prevention and Rehabilitation, the American Association of Cardiovascular and Pulmonary Rehabilitation and the Canadian Association of Cardiac Rehabilitation. Eur. J. Prev. Cardiol.
20, 442–467 (2013).
Godin, G. & Shephard, R. J. A simple method to assess exercise behavior in the community. Can. J. Appl. Sport Sci.
10, 141–146 (1985).
Schmitz, K. H. et al. American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci. Sports Exerc
42, 1409–1426 (2010).
Yellen, S. B., Cella, D. F., Webster, K., Blendowski, C. & Kaplan, E. Measuring fatigue and other anemia-related symptoms with the Functional Assessment of Cancer Therapy (FACT) measurement system. J. Pain. Symptom Manag.
13, 63–74 (1997).
Kohout, F. J., Berkman, L. F., Evans, D. A. & Cornoni-Huntley, J. Two shorter forms of the CES-D (Center for Epidemiological Studies Depression) depression symptoms index. J. Aging Health
5, 179–193 (1993).
Spielberger, C. D, Gorsuch, R. L, Lushene, R, Vagg, P. R. & Jacobs, G. A. Manual For The State-trait Anxiety Inventory. (Consulting Psychologists Press, Palo Alto, 1983).
Cohen, S., Kamarck, T. & Mermelstein, R. A global measure of perceived stress. J. Health Soc. Behav.
24, 385–396 (1983).
Rosenberg, M Society And The Adolescent Self-image. Vol.11 (Princeton University Press, Princeton, 1965).
Beck, S. L., Schwartz, A. L., Towsley, G., Dudley, W. & Barsevick, A. Psychometric evaluation of the Pittsburgh Sleep Quality Index in cancer patients. J. Pain. Symptom Manag.
27, 140–148 (2004).
Ware, J. E et al. User’s Manual for the SF-36v2 Health Survey. 2nd edn. (Quality Metric Incorporated, Lincoln, 2011).
MacKinnon, D. P Introduction To Statistical Mediation Analysis. (Lawrence Erlbaum Associates, New York, 2008).
Hayes, A. F Introduction To Mediation, Moderation, And Conditional Process Analysis: A Regression-based Approach. 2nd edn. (Guilford Press, New York, 2013).
Preacher, K. J. & Hayes, A. F. SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav. Res Methods Instrum. Comput.
36, 717–731 (2004).
Borm, G. F., Fransen, J. & Lemmens, W. A. A simple sample size formula for analysis of covariance in randomised clinical trials. J. Clin. Epidemiol.
60, 1234–1238 (2007).
Cella, D., Eton, D. T., Lai, J. S., Peterman, A. H. & Merkel, D. E. Combining anchor and distribution-based methods to derive minimal clinically important differences on the Functional Assessment of Cancer Therapy (FACT) anemia and fatigue scales. J. Pain. Symptom Manag.
24, 547–561 (2002).
Daussin, F. N. et al. Effect of interval versus continuous training on cardiorespiratory and mitochondrial functions: relationship to aerobic performance improvements in sedentary subjects. Am. J. Physiol. Regul. Integr. Comp. Physiol.
295, R264–R272 (2008).
Wisloff, U. et al. Superior cardiovascular effect of aerobic interval training versus moderate continuous training in heart failure patients: A randomised study. Circulation
115, 3086–3094 (2007).
Cormie, P. et al. Can supervised exercise prevent treatment toxicity in patients with prostate cancer initiating androgen-deprivation therapy: a randomised controlled trial. BJU Int.
115, 256–266 (2015).
Burney, B. O. & Garcia, J. M. Hypogonadism in male cancer patients. J. Cachex-. Sarcopenia Muscle
3, 149–155 (2012).
Bhasin, S. Testosterone supplementation for aging-associated sarcopenia. J. Gerontol. A Biol. Sci. Med Sci.
58, 1002–1008 (2003).
Caminiti, G. et al. Effect of long-acting testosterone treatment on functional exercise capacity, skeletal muscle performance, insulin resistance, and baroreflex sensitivity in elderly patients with chronic heart failure: a double-blind, placebo-controlled, randomised study. J. Am. Coll. Cardiol.
54, 919–927 (2009).
Courneya, K. S. et al. Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomised controlled trial. J. Clin. Oncol.
25, 4396–4404 (2007a).
Rossen, P., Pedersen, A. F., Zachariae, R. & von der Maase, H. Sexuality and body image in long-term survivors of testicular cancer. Eur. J. Cancer
48, 571–578 (2012).
van Basten, J. P. et al. Fantasies and facts of the testes. Br. J. Urol.
78, 756–762 (1996).
Courneya, K. S. et al. Six-month follow-up of patient-rated outcomes in a randomised controlled trial of exercise training during breast cancer chemotherapy. Cancer Epidemiol. Biomark. Prev.
16, 2572–2578 (2007b).
Rogers, L. Q. et al. Physical activity and health outcomes three months after completing a physical activity behavior change intervention: persistent and delayed effects. Cancer Epidemiol. Biomark. Prev.
18, 1410–1418 (2009).