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Building a hematopoietic cell transplantation outcomes registry in Mexico

Bone Marrow Transplantation volume 55, pages 2279–2285 (2020)Cite this article

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Abstract

The aim of this study was to assess the feasibility of hematopoietic cell transplantation (HCT) data collection using an electronic platform at Mexican centers. Four public centers performing HCT in adults were included. A cloud-based electronic platform in Spanish was developed to allow real-time registration of demographic, clinical, and outcomes variables. Data were obtained from paper and electronic medical records and institutional databases. Data managers were hired to perform the collection. Data from January 2015 to December 2018 were retro and prospectively collected during a 10-month period. From 2015 to 2018, 473 HCT were performed. Most were autologous (55%). Patients undergoing autologous HCT had the highest median age (49 years) compared with patients undergoing allogeneic (34 years) or haploidentical HCT (29 years). The most common underlying disease for autologous HCT was multiple myeloma. Acute leukemias were the most common diagnoses among allogeneic and haploidentical HCT recipients. Two-year nonrelapse mortality was 2.5%, 18%, and 18% for autologous, allogeneic, and haploidentical HCT, respectively. We determined it was feasible to start a multicenter collaborative study in Mexico as it was very well received by the physicians and it can lead to the creation of a Mexican HCT Registry in the near future.

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Fig. 1: Algorithm of data collection.
Fig. 2: Number of HCT by type and year.
Fig. 3

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References

  1. Gratwohl A, Pasquini MC, Aljurf M, Atsuta Y, Baldomero H, Foeken L, et al. One million haemopoietic stem-cell transplants: a retrospective observational study. Lancet Haematol. 2015;2:e91–100.

    Article  Google Scholar 

  2. Ruiz-Argüelles GJ, Abello-Polo V, Arrais-Rodrígues C, Bouzas LF, de Souza C, Dufort G, et al. Publications of bone marrow transplants in Latin America. A report of the Latin American Group of Bone Marrow Transplantation. Bone Marrow Transplant. 2015;50:1130–1.

    Article  Google Scholar 

  3. Jaimovich G, Martinez-Rolon J, Baldomero H, Rivas M, Hanesman I, Bouzas L, et al. Latin America: the next region for haematopoietic transplant progress. Bone Marrow Transplant. 2017;52:671–7.

    Article  CAS  Google Scholar 

  4. Gale RP, Seber A, Bonfim C, Pasquini M. Haematopoietic cell transplants in Latin America. Bone Marrow Transplant. 2016;51:898–905.

    Article  CAS  Google Scholar 

  5. Chandy M, Srivastava A, Dennison D, Mathews V, George B. Allogeneic bone marrow transplantation in the developing world: experience from a center in India. Bone Marrow Transplant. 2001;27:785–90.

    Article  CAS  Google Scholar 

  6. Gratwohl A, Baldomero H, Aljurf M, Pasquini MC, Bouzas LF, Yoshimi A, et al. Hematopoietic stem cell transplantation: a global perspective. JAMA 2010;303:1617–24.

    Article  CAS  Google Scholar 

  7. Sharma SK, Choudhary D, Gupta N, Dhamija M, Khandelwal V, Kharya G, et al. Cost of hematopoietic stem cell transplantation in India. Mediterr J Hematol Infect Dis. 2014;6:e2014046.

    Article  Google Scholar 

  8. Al-Khabori M, Al-Huneini M. Hematopoietic stem cell transplantation in the Sultanate of Oman. Hematol Oncol Stem Cell Ther. 2017;10:305–7.

    Article  Google Scholar 

  9. Limón Flores JA. El trasplante de células hematopoyéticas en México. Una perspectiva desde la III Jornada Académica de Trasplante Hematopoyético en el IMSS de Puebla. Rev Hematol Mex. 2018;19:101–4.

    Google Scholar 

  10. Passweg JR, Baldomero H, Bader P, Bonini C, Cesaro S, Dreger P. Hematopoietic stem cell transplantation in Europe 2014: more than 40 000 transplants annually. Bone Marrow Transplant. 2016;51:786–92.

    Article  CAS  Google Scholar 

  11. Majhail NS, Omondi NA, Denzen E, Murphy EA, Rizzo JD. Access to hematopoietic cell transplantation in the United States. Biol Blood Marrow Transplant. 2009;16:1070–5.

    Article  Google Scholar 

  12. Gratwohl A, Baldomero H, Gratwohl M, Aljurf M, Bouzas LF, Horowitz M, et al. Quantitative and qualitative differences in use and trends of hematopoietic stem cell transplantation: a global observational study. Haematologica. 2013;98:1282–90.

    Article  Google Scholar 

  13. Niederwieser D, Baldomero H, Szer J, Gratwohl M, Aljurf M, Atsuta Y, et al. Hematopoietic stem cell transplantation activity worldwide in 2012 and a SWOT analysis of the Worldwide Network for Blood and Marrow Transplantation Group including the global survey. Bone Marrow Transplant. 2016;51:778–85.

    Article  CAS  Google Scholar 

  14. D’Souza A, Fretham C. Current uses and outcomes of hematopoietic cell transplantation (HCT): CIBMTR summary slides. 2019. http://www.cibmtr.org.

  15. Hussain F, Chaudhri N, Alfraih F, Aljurf M. Current concepts on hematopoietic stem cell transplantation outcome registries; emphases on resource requirements for new registries. Hematol Oncol Stem Cell Ther. 2017;10:203–10.

    Article  Google Scholar 

  16. Rivera Franco MM, Leon Rodriguez E. Importance of non-governmental organizations for the establishment of a successful hematopoietic stem cell transplantation program in a developing country. J Glob Oncol. 2018;4:1–8.

    PubMed  Google Scholar 

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Acknowledgements

We would like to thank the data managers Edgar, Margarita, and Melissa who participated in this project.

Funding

This work was funded by a 2018 Conquer Cancer Foundation of ASCO Global Oncology Young Investigator Award (ID 12996). Any opinions, findings, and conclusions expressed in this material are those of the authors and do not necessarily reflect those of the American Society of Clinical Oncology® or the Conquer Cancer Foundation.

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Authors and Affiliations

  1. Hematopoietic Stem Cell Transplantation Program, Department of Hematology and Oncology, Instituto Nacional de Ciencias Medicas y Nutricion “Salvador Zubiran”, Mexico City, Mexico

    Monica M. Rivera-Franco & Eucario Leon-Rodriguez

  2. Hematology Service, Hospital Universitario “Dr. José Eleuterio González”, Universidad Autónoma de Nuevo León, Monterrey, NL, Mexico

    David Gómez-Almaguer & Cesar H. Gutiérrez-Aguirre

  3. Hematopoietic Stem Cell Transplantation Program, Department of Hematology, Instituto Nacional de Cancerología, Mexico City, Mexico

    Luis M. Valero-Saldaña & Brenda L. Acosta-Maldonado

  4. Hematology Service, Unidad Médica de Alta Especialidad “Manuel Avila Camacho”, Instituto Mexicano del Seguro Social, Puebla, PL, Mexico

    Jose A. Limón-Flores & Uendy Pérez-Lozano

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  1. Monica M. Rivera-Franco
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  2. Eucario Leon-Rodriguez
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Correspondence to Eucario Leon-Rodriguez.

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Rivera-Franco, M.M., Leon-Rodriguez, E., Gómez-Almaguer, D. et al. Building a hematopoietic cell transplantation outcomes registry in Mexico. Bone Marrow Transplant 55, 2279–2285 (2020). https://doi.org/10.1038/s41409-020-0944-z

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