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Colistin-resistant Klebsiella pneumoniae co-harboring KPC and MCR-1 in a Hematopoietic Stem Cell Transplantation Unit

Bone Marrow Transplantation volume 54, pages 1118–1120 (2019)Cite this article

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Carbapenem-resistant Klebsiella pneumoniae (CRK) infections have increased all over the world, becoming an important pathogen in immunocompromised patients that is associated with high morbidity and mortality [1]. Colistin is commonly used as a last resort treatment of CRK infections but the description of a plasmid-mediated resistance gene mcr-1 in 2015 raised concerns about antibiotic resistance in Enterobacteriaceae[2].

Hematopoietic stem cell transplant (HSCT) patients, especially during the neutropenic phase before engraftment, are vulnerable to infections from healthcare-associated bacteria but there are few reports of colistin-resistant CRK infections in this population.

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References

  1. Oliveira AL, De Souza M, Carvalho-Dias VMH, Ruiz MA, Silla L, Tanaka PY, et al. Epidemiology of bacteremia and factors associated with multi-drug-resistant gram-negative bacteremia in hematopoietic stem cell transplant recipients. Bone Marrow Transplant. 2007;39:775–81.

    Article  CAS  Google Scholar 

  2. Liu Yi-Yun, Wang Y, Walsh TR, Yi L-X, Zhang R, Spencer J, et al. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infect Dis. 2016;16:161–68.

    Article  Google Scholar 

  3. Assefa S, Keane TM, Otto TD, Newbold C, Berriman M. ABACAS: algorithm-based automatic contiguation of assembled sequences. Bioinforma Oxf Engl. 2009;25:1968–9.

    Article  CAS  Google Scholar 

  4. Seemann T. Prokka: rapid prokaryotic genome annotation. Bioinforma Oxf Engl. 2014;30:2068–9.

    Article  CAS  Google Scholar 

  5. Larsen MV, Cosentino S, Rasmussen S, Friis C, Hasman H, Marvig RL, et al. Multilocus sequence typing of total-genome-sequenced bacteria. J Clin Microbiol. 2012;50:1355–61.

    Article  CAS  Google Scholar 

  6. Zankari E, Hasman H, Cosentino S, Vestergaard M, Rasmussen S, Lund O, et al. Identification of acquired antimicrobial resistance genes. J Antimicrob Chemother. 2012;67:2640–4.

    Article  CAS  Google Scholar 

  7. Bonomo RA, Burd EM, Conly J, Limbago BM, Poirel L, Segre JA, et al. Carbapenemase-producing organisms: A Global Scourge. Clin Infect Dis. 2018;66:1290–7.

    Article  CAS  Google Scholar 

  8. Wang R, van Dorp L, Shaw LP, Bradley P, Wang Q, Wang X, et al. The global distribution and spread of the mobilized colistin resistance gene mcr-1. Nat Commun. 2018;9:1179.

    Article  Google Scholar 

  9. Conceição-Neto OC, Aires CAM, Pereira NF, da Silva LHJ, Picão RC, Siqueira BN, et al. Detection of the plasmid-mediated mcr-1 gene in clinical KPC-2-producing Escherichia coli isolates in Brazil. Int J Antimicrob Agents. 2017;50:282–4.

    Article  Google Scholar 

  10. Dalmolin TV, Martins AF, Zavascki AP, de Lima-Morales D, Barth AL. Acquisition of the mcr-1 gene by a high-risk clone of KPC-2-producing Klebsiella pneumoniae ST437/CC258, Brazil. Diagn Microbiol Infect Dis. 2018;90:132–3.

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Departmento de Moléstias Infecciosas e Parasitárias, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Hermes Ryoiti Higashino, Marjorie Vieira Batista, Anna Sara Levin & Silvia Figueiredo Costa

  2. Laboratório de Investigação Médica em Protozoologia, Bacteriologia e Resistência Antimicrobiana - LIM/49, Faculdade de Medicina FMUSP, Universidade de São Paulo, São Paulo, Brazil

    Ana Paula Marchi, Roberta Cristina Ruedas Martins, Lauro Vieira Perdigão Neto, Victor Augusto Camarinha de Castro Lima, Anna Sara Levin & Silvia Figueiredo Costa

  3. Departmento de Patologia, Divisão de Microbiologia do Laboratório Central - LIM/03, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Flavia Rossi

  4. Comissão de Controle de Infecção Hospitalar do Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Thais Guimarães

  5. Departmento de Hematologia, Hemoterapia e Terapia Celular, Hospital das Clínicas HCFMUSP, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil

    Vanderson Rocha

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  1. Hermes Ryoiti Higashino
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Correspondence to Hermes Ryoiti Higashino.

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Higashino, H.R., Marchi, A.P., Martins, R.C.R. et al. Colistin-resistant Klebsiella pneumoniae co-harboring KPC and MCR-1 in a Hematopoietic Stem Cell Transplantation Unit. Bone Marrow Transplant 54, 1118–1120 (2019). https://doi.org/10.1038/s41409-018-0416-x

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