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The impact of counseling on nutritional status among hematopoietic stem cell recipients: results of a randomized controlled trial

Bone Marrow Transplantation volume 54, pages 752–756 (2019)Cite this article

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Conditioning regimen accompanying hematopoietic stem cell transplantation (HSCT) is associated with severe gastro-intestinal toxicity, commonly compromising patients’ food intake, nutritional status, and functioning level [1, 2]. Studies assessing malnutrition rates in HSCT showed that malnutrition rates are low at admission (ranging between 4 and 6%), elevated at hospital discharge (ranging between 35 and 60%), and gradually decreases post discharge [2, 3]. A prospective cohort study suggested that even though patients had improved quality of life, physical activity levels, and lean body mass post HSCT, they did not regain their pre-HSCT levels 100 days post transplantation compared to admission. All patients at discharge and half the patients 100 days post HSCT required a nutrition intervention, when assessed with the patient-generated subjective global assessment (PGSGA) nutritional assessment tool [2].

Nutrition support recommended as part of a model for cancer cachexia rehabilitation was associated with an improved nutritional status among cancer patients [4]. The effect of nutritional counseling has not been well studied among HSCT post hospital discharge. The aim of this open-label randomized controlled trial (RCT) was to assess the effect of nutritional counseling provided monthly at and post hospital discharge on nutritional status at 100 days post HSCT.

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Acknowledgements

The research team would like to acknowledge the patients who consecrated their time and effort to participate in this study, the nursing teams in the BMT and 8 North Units, and the clinic assistant in the Bariatric Unit in AUBMC for their collaboration in supporting patient assessment, and Dr. Adham Abou Ali for his support of the study design. JJ would like to acknowledge the training received under the Scholars in Health Research Program that supported her translational and research skills.

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Authors and Affiliations

  1. Department of Clinical Nutrition, American University of Beirut Medical Center, Beirut, Lebanon

    Jana Jabbour LD, MPH, PhD & May Sakr LD, MPH

  2. Ecole Doctorale Sciences de la Vie et de la Santé, Aix Marseille Université, Marseille, France

    Jana Jabbour LD, MPH, PhD & Didier Blaise MD

  3. Division of Hematology/Oncology, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

    Batoul Manana LD

  4. Bone Marrow Transplantation Program, Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon

    Ammar Zahreddine RN, Ali Bazarbachi MD, PhD & Jean El-Cheikh MD

  5. Clinical Research Unit, American University of Beirut of Medical Center, Beirut, Lebanon

    Hani Tamim MPH, PhD

  6. Hematology Department, Transplantation Unit, Paoli Calmettes Institute, Marseille, France

    Didier Blaise MD

  7. Centre de Recherche sur le Cancer de Marseille, Inserm U 1068, Marseille, France

    Didier Blaise MD

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  1. Jana Jabbour LD, MPH, PhD
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  8. Jean El-Cheikh MD
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Corresponding author

Correspondence to Jean El-Cheikh MD.

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The study obtained approval from the Institutional Review Board at the American University of Beirut.

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The authors declare that they have no conflict of interest.

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Jabbour, J., Manana, B., Sakr, M. et al. The impact of counseling on nutritional status among hematopoietic stem cell recipients: results of a randomized controlled trial. Bone Marrow Transplant 54, 752–756 (2019). https://doi.org/10.1038/s41409-018-0366-3

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