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Risk factors associated with development and mortality by invasive fungal diseases in pediatric allogeneic stem cell transplantation. A pediatric subgroup analysis of data from a prospective study of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO)

Bone Marrow Transplantation volume 53, pages 1193–1197 (2018)Cite this article

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Allogeneic hemopoietic stem cell transplant (HSCT) is a high-risk procedure for development of invasive fungal diseases (IFD) in children. Pre-engraftment neutropenia and severe Graft vs. host disease (GvHD) represent probably the most known, risk factors [1,2,3], but other factors like age, type of donor, and immunosuppressive therapy have also been reported [1, 3,4,5,6,7,8,9].

In 2014 the Gruppo Italiano Trapianto di Midollo Osseo (GITMO) published a nationwide prospective survey performed in the period 2008–2010 on risk factors for IFD and IFD-related mortality in the first year after allogeneic HSCT [10]. This original study included both adults and children, but a specific pediatric subpopulation analysis was not performed.

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Author contributions

EC: study design, data analysis, manuscript preparation, FB: data analysis and manuscript revision, SM: data revision and analysis, MM: data collection, revision and analysis, AP: data collection and revision, TB: data collection and revision, API: data collection and revision, WB: data collection and revision, AS: data collection and revision, AP: data collection and revision, AMR: study design, data collection and revision, AV: data collection and revision, LC: data collection and revision, AR study design, manuscript revision, CG: study design, manuscript revision

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Authors and Affiliations

  1. Istituto Giannina Gaslini, Genova, Italy

    Elio Castagnola, Francesca Bagnasco, Stefania Menoni & Monica Muraca

  2. Oncology, Hematology and HematopoieticStem Cell Transplant Program, U.O. Pediatrics- S. Orsola-Malpighi University of Bologna, Bologna, Italy

    Arcangelo Prete & Tamara Belotti

  3. Department of Hematology, Azienda Policlinico Umberto I, Sapienza University of Roma, Roma, Italy

    Anna Paola Iori, Walter Barberi & Corrado Girmenia

  4. Unit of Hematology and Stem Cell Transplant, Azienda Ospedaliera S. Camillo-Forlanini, Roma, Italy

    Alessandro Severino & Anna Proia

  5. Division of Hematology II, IRCCS, San Martino University Hospital e IST, Genova, Italy

    Anna Maria Raiola

  6. Hematology, Bone Marrow Transplant Center, Presidio Ospedaliero Roberto Binaghi, Cagliari, Italy

    Adriana Vacca

  7. Stem Cell Transplant Unit, Fondazione Policlinico Tor Vergata, Tor Vergata University, Roma, Italy

    Laura Cudillo

  8. Division of Hematology, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy

    Alessandro Rambaldi

Authors
  1. Elio Castagnola
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  2. Francesca Bagnasco
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  11. Anna Maria Raiola
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  15. Corrado Girmenia
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Correspondence to Elio Castagnola.

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Castagnola, E., Bagnasco, F., Menoni, S. et al. Risk factors associated with development and mortality by invasive fungal diseases in pediatric allogeneic stem cell transplantation. A pediatric subgroup analysis of data from a prospective study of the Gruppo Italiano Trapianto di Midollo Osseo (GITMO). Bone Marrow Transplant 53, 1193–1197 (2018). https://doi.org/10.1038/s41409-018-0160-2

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