Abstract
According to current cosmological theory, the universe will continue to expand indefinitely. If so, it should cool eventually reaching temperatures too cold to sustain life. This theory is commonly referred to as heat-death or the big freeze. Putting aside this potentially unpleasant scenario, unlikely in the lifetime of current readers (about 10 × E + 2500 years from now), freezing, in contrast, has played an important role in hematopoietic cell autotransplants for disease such as plasma cell myeloma and lymphomas. Let us consider how.
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References
Debelak-Fehir KM, Catchatourian R, Epstein RB. Hemopoietic colony forming units in fresh and cryopreserved peripheral blood cells of canines and man. Exp Hematol. 1975;3:109–16.
Epstein RB, Sarpel SC. Processing of peripheral blood stem cells for transplantation. Exp Hematol. 1979;7(Suppl 5):125–34.
Fliedner TM, Calvo W, Körbling M, Nothdurft W, Pflieger H, Ross W. Collection, storage and transfusion of blood stem cells for the treatment of hemopoietic failure. Blood Cells. 1979;5:313–28.
Storb R, Graham TC, Epstein RB, Sale GE, Thomas ED. Demonstration of hemopoietic stem cells in the peripheral blood of baboons by cross circulation. Blood. 1977;50:537–42.
Gough NM, Gough J, Metcalf D, Kelso A, Grail D, Nicola NA, Burgess AW, et al. Molecular cloning of cDNA encoding a murine haematopoietic growth regulator, granulocyte-macrophage colony stimulating factor. Nature. 1884;309:763–7.
Gale RP, Vorobiov A. First use of myeloid colony-stimulating factors in humans (letter to the editor). Bone Marrow Transplant. 2013;48:1358.
Gale RP, Lazarus H. A rose by any other name would smell as sweet, or would it?. Bone Marrow Transplant. 2013;48:881–3.
Polge C. Low-temperature storage of mammalian spermatozoa. Proc R Soc Lond B Biol Sci. 1957;147:498–508.
Mazur P. Stopping biological time. The freezing of living cells. Ann N Y Acad Sci. 1988;541:514–31.
Ruiz-Argüelles GJ, Ruiz-Argüelles A, Pérez-Romano B, Marín-López A, Delgado-Lamas JL. Non-cryopreserved peripheral blood stem cells autotransplants for hematological malignancies can be performed entirely on an outpatient basis. Am J Hematol. 1998;58:161–4.
Karduss-Urueta A, Ruiz-Arguelles GJ, Perez R, Ruiz-Delgado GJ, Cardona AM, Labastida-Mercado N, et al. Cell-freezing devices are not strictly needed to start an autologous hematopoietic transplantation program: non-cryopreserved peripheral blood stem cells can be used to restore hematopoiesis after high dose chemotherapy: a multicenter experience in 268 autografts in patients with multiple myeloma or lymphoma. Study on behalf of the Latin-American Bone Marrow Transplantation Group (LABMT). Blood. 2014;124:849.
Ruiz-Argüelles GJ, Steensma DP. Staunching the rising costs of haematological health care. Lancet Haematol. 2016;3:10.
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Gale, R.P., Ruiz-Argüelles, G.J. The big freeze may be over: a contracting universe for cryopreservation?. Bone Marrow Transplant 53, 947–948 (2018). https://doi.org/10.1038/s41409-018-0119-3
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DOI: https://doi.org/10.1038/s41409-018-0119-3
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