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Epithelial chimerism in lung tissue after allogeneic hematopoietic stem cell transplantation

Bone Marrow Transplantation volume 53, pages 474–477 (2018)Cite this article

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Late-onset non-infectious pulmonary manifestations are frequent after allogeneic hematopoietic stem cell transplantation (HSCT). Among them chronic pulmonary graft versus host disease (GVHD) may lead to bronchiolitis obliterans and/or interstitial lung disease [1].

The lungs are characterized by a limited regenerative capacity. A slow repair process exists however, involving probably local endogenous progenitor cells, as well as mobilization of non-hematopoietic endothelial and mesenchymal progenitors from the bone [2, 3].

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Acknowledgements

The authors thank Polly Gobin for English language reviewing. They also thank the other members of The Lung Study Group of Foch for Immunosuppressed Patients for their dedication and their daily work with patients. Pulmonology: Dr. Colas Tcherakian, Dr. Alexandre Chabrol; Thoracic Surgery: Dr. Edouard Sage, Dr. Pierre Bonnette, Dr. Philippe; Puyo Intensive Care: Dr. François Parquin, Dr. Grégoire Trebbia; Radiology: Dr. François Mellot, Dr. Axel Guth, Dr. Fabrice Staub, Dr. Marie-Laure Chabi-Charvillat; and Microbiology: Dr. Eric Farfour, Dr. Emilie Cardot, Dr. Pierre Cahen.

Author contributions

JA analyzed clinical data, wrote the manuscript. CBC designed and performed pathological techniques. ZL designed and performed pathological techniques. CE designed research and analyzed data. MN performed pathological techniques. RE analyzed data. NS, RMT, BC addressed patients, corrected the manuscript. LE designed and performed pathological techniques. TC analyzed data. CLJ designed research and analyzed data. SH designed research, analyzed data, and wrote the manuscript.

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Author notes

  1. M. T. Rubio

    Present address: Hôpital Brabois, CHRU Nancy, Service d’Hématologie, Vandoeuvre les Nancy, France

Authors and Affiliations

  1. Hôpital FOCH, Service de Pneumologie, Suresnes, France

    A. Judet, E. Catherinot, E. Rivaud, C. Tcherakian, L. J. Couderc & H. Salvator

  2. Département de Pathologie, AP-HP, Groupe Henri Mondor-Albert Chenevier, F-94010, Créteil, France

    C. Copie-Bergman

  3. Faculté de Médecine, Universite Paris-Est, UMR-S 955, F-94010, Créteil, France

    C. Copie-Bergman & N. Martin

  4. INSERM, Unité U955, F-94010, Créteil, France

    C. Copie-Bergman & N. Martin

  5. Département de Pathologie, Hôpital FOCH, Suresnes, France

    L. Zemoura & E. Longchampt

  6. APHP, Hôpital Pitié-Salpétrière, Service d’Hématologie, Paris, France

    S. Nguyen

  7. APHP, Hôpital Saint-Antoine, Service d’Hématologie, Paris, France

    M. T. Rubio

  8. CHU Rennes Pontchaillou, Service de Pneumologie, Rennes, France

    C. Belleguic

  9. Université Versailles Saint Quentin, UFR des Sciences de la santé Simone Veil, Montigny-le-Bretonneux, France

    C. Tcherakian, L. J. Couderc & H. Salvator

  10. UPRES EA 220, Suresnes, France

    C. Tcherakian, L. J. Couderc & H. Salvator

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  1. A. Judet
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  11. C. Tcherakian
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  13. H. Salvator
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The Lung Study Foch Hospital Group for Immunosuppressed Patients

Corresponding author

Correspondence to H. Salvator.

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Conflict of interest

CLJ participated in a board on immunodeficiencies financed by CSL Behring. The remaining authors declare no competing financial interests.

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Judet, A., Copie-Bergman, C., Zemoura, L. et al. Epithelial chimerism in lung tissue after allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 53, 474–477 (2018). https://doi.org/10.1038/s41409-017-0050-z

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