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Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients

The Pharmacogenomics Journal volume 20, pages 388–397 (2020)Cite this article

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Abstract

The effect of polymorphims in leptin and adiponectin genes on long-term outcomes of renal transplantation is unknown. In 349 renal transplant recipients (RTR), we aimed to determine associations between five SNPs in the leptin receptor (LEPR) and adiponectin (ADIPOQ) genes and these outcomes. Follow-up time ranged from 2 to 25 years (mean 10.29 ± 5.16 years). Two SNPs showed associations with long-term outcomes and their statistical significance greatly increased after 39 RTR with a history of cardiovascular events prior to transplantation were removed from the analysis. Adjusted odds ratios (OR) for LEPR rs1805094 and ADIPOQ rs1501299 and risk of graft loss were 0.35 (0.16–0.74) p = 0.006 and 2.37 (1.28–4.37) p = 0.006, respectively. The assessment of risk for global mortality revealed OR values of 0.20 (0.06–0.62), p = 0.005, and 2.43 (1.08–5.44), p = 0.031 for LEPR rs1805094 and ADIPOQ rs1501299, respectively. Our results show that polymorphism in genes involved in leptin and adiponectin function modify long-term outcomes in renal transplantation.

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Acknowledgements

The authors want to thank the technical and human support provided by the Facility of Bioscience Applied Techniques of SAIUEx (financed by UEX, Junta de Extremadura, MICINN, FEDER and FSE). This work has been supported in part by grants PI15/00804 and PI18/00745 from Instituto de Salud Carlos III, Madrid (Spain), and grants IB16014 and GR18007 from Junta de Extremadura, Mérida (Spain) and Fondo Europeo de Desarrollo Regional (FEDER) “Una manera de hacer Europa”.

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Authors and Affiliations

  1. Department of Medical and Surgical Therapeutics, Medical School, University of Extremadura, Badajoz, Spain

    Guillermo Gervasini, Guadalupe García-Pino & Sonia Mota-Zamorano

  2. Service of Nephrology, Hospital de Zafra, Extremadura, Spain

    Guadalupe García-Pino

  3. Service of Nephrology, University Hospital, Badajoz, Spain

    Enrique Luna & Juan José Cubero

  4. Service of Clinical Analyses, Don Benito-Villanueva Hospital, Villanueva de la Serena, Spain

    Montserrat García-Cerrada

  5. Deparment of Physiology, Medical School, University of Extremadura, Badajoz, Spain

    María Ángeles Tormo

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Gervasini, G., García-Pino, G., Mota-Zamorano, S. et al. Association of polymorphisms in leptin and adiponectin genes with long-term outcomes in renal transplant recipients. Pharmacogenomics J 20, 388–397 (2020). https://doi.org/10.1038/s41397-019-0128-7

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