The Red Section | Published:

Functional Dyspepsia – A Revolution in Management

The American Journal of Gastroenterology (2018) | Download Citation


Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. 1.

    Oshima T, Miwa H. Epidemiology of functional gastrointestinal disorders in japan and in the world. J Neurogastroenterol Motil. 2015;21:320–9.

  2. 2.

    Stanghellini V, Chan FK, Hasler WL, et al. Gastroduodenal disorders. Gastroenterology. 2016;150:1380–92.

  3. 3.

    Moayyedi P, Lacy BE, Andrews CN, et al. ACG and CAG clinical guideline: management of dyspepsia. Am J Gastroenterol. 2017;112:988–1013.

  4. 4.

    Miwa H, Kusano M, Arisawa T, et al. Evidence-based clinical practice guidelines for functional dyspepsia. J Gastroenterol. 2015;50:125–39.

  5. 5.

    Miwa H. Clinical management of functional dyspepsia - is the management changed after publication of Japanese FD guideline? Nihon Shokakibyo Gakkai Zasshi. 2016;113:919–26.

  6. 6.

    Mearin F. Irritable bowel syndrome: pain in Spain. Am J Gastroenterol. 2017;112:1768–9.

  7. 7.

    Vanheel H, Carbone F, Valvekens L, et al. Pathophysiological abnormalities in functional dyspepsia subgroups according to the Rome III criteria. Am J Gastroenterol. 2017;112:132–40.

  8. 8.

    Asano H, Tomita T, Nakamura K, et al. Prevalence of gastric motility disorders in patients with functional dyspepsia. J Neurogastroenterol Motil. 2017;23:392–9.

  9. 9.

    DiBaise JK, Patel N, Noelting J, et al. The relationship among gastroparetic symptoms, quality of life, and gastric emptying in patients referred for gastric emptying testing. Neurogastroenterol Motil. 2016;28:234–42.

  10. 10.

    Taki M, Oshima T, Takimoto M, et al. Duodenal low-grade inflammation and tight junction proteins in functional dyspepsia. Gastroenterology. 2017;152:S167–8.

  11. 11.

    Friesen CA, Andre L, Garola R, et al. Activated duodenal mucosal eosinophils in children with dyspepsia: a pilot transmission electron microscopic study. J Pediatr Gastroenterol Nutr. 2002;35:329–33.

  12. 12.

    Vanheel H, Vicario M, Vanuytsel T, et al. Impaired duodenal mucosal integrity and low-grade inflammation in functional dyspepsia. Gut. 2014;63:262–71.

  13. 13.

    Sugano K, Tack J, Kuipers EJ, et al. Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 2015;64:1353–67.

  14. 14.

    Pinto-Sanchez MI, Yuan Y, Hassan A, et al. Proton pump inhibitors for functional dyspepsia. Cochrane Database Syst Rev. 2017;11:CD011194.

  15. 15.

    Oshima T, Okugawa T, Tomita T, et al. Generation of dyspeptic symptoms by direct acid and water infusion into the stomachs of functional dyspepsia patients and healthy subjects. Aliment Pharmacol Ther. 2012;35:175–82.

  16. 16.

    Ishii M, Kusunoki H, Manabe N, et al. Evaluation of duodenal hypersensitivity induced by duodenal acidification using transnasal endoscopy. J Gastroenterol Hepatol. 2010;25:913–8.

  17. 17.

    Tack J, Pokrotnieks J, Urbonas G, et al. Long-term safety and efficacy of acotiamide in functional dyspepsia (postprandial distress syndrome)-results from the European phase 3 open-label safety trial. Neurogastroenterol Motil. 2018;30:e13284.

  18. 18.

    Matsueda K, Hongo M, Tack J, et al. A placebo-controlled trial of acotiamide for meal-related symptoms of functional dyspepsia. Gut. 2012;61:821–8.

  19. 19.

    Tominaga K, Sakata Y, Kusunoki H, et al. Rikkunshito simultaneously improves dyspepsia correlated with anxiety in patients with functional dyspepsia: a randomized clinical trial (the DREAM study). Neurogastroenterol Motil. 2018;30:e13319.

  20. 20.

    Nakamura K, Tomita T, Oshima T, et al. A double-blind placebo-controlled study of acotiamide hydrochloride for efficacy on gastrointestinal motility of patients with functional dyspepsia. J Gastroenterol. 2017;52:602–10.

Download references

Author information


  1. Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan

    • Tadayuki Oshima MD, PhD
    •  & Hiroto Miwa MD, PhD


  1. Search for Tadayuki Oshima MD, PhD in:

  2. Search for Hiroto Miwa MD, PhD in:

Guarantors of the article

Tadayuki Oshima, MD, PhD.

Specific author contributions

Tadayuki Oshima contributed to writing of this manuscript. Hiroto Miwa contributed to conception and supervision of this manuscript. All authors approved the final draft that is submitted.

Financial support


Potential competing interests


Corresponding author

Correspondence to Tadayuki Oshima MD, PhD.

About this article

Publication history