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The Anti-α4β7 Integrin Therapeutic Antibody for Inflammatory Bowel Disease, Vedolizumab, Ameliorates Eosinophilic Esophagitis: a Novel Clinical Observation

The American Journal of Gastroenterologyvolume 113pages12611263 (2018) | Download Citation

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References

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    Nhu QM, Aceves SS. Tissue remodeling in chronic eosinophilic esophageal inflammation: parallels in asthma and therapeutic perspectives. Front Med (Lausanne). 2017;4:128.

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    Walsh GM, Symon FA, Lazarovils AL, et al. Integrin α4β7 mediates human eosinophil interaction with MAdCAM-1, VCAM-1 and fibronectin. Immunology. 1996;89:112–9.

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    Meerschaert J, Vrtis RF, Shikama Y, et al. Engagement of α4β7 integrins by monoclonal antibodies or ligands enhances survival of human eosinophils in vitro. J Immunol. 1999;163:6217–27.

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Author information

Affiliations

  1. Division of Gastroenterology & Hepatology, Scripps Clinic, La Jolla, CA, USA

    • Quan M. Nhu MD, PhD
    • , Hellen Chiao MD
    • , Fouad J. Moawad MD
    •  & Gauree G. Konijeti MD, MPH
  2. Department of Medicine, Scripps Clinic – Scripps Green Hospital, La Jolla, CA, USA

    • Quan M. Nhu MD, PhD
  3. Scripps Translational Science Institute, The Scripps Research Institute, La Jolla, CA, USA

    • Quan M. Nhu MD, PhD
    •  & Gauree G. Konijeti MD, MPH
  4. Department of Pathology, Scripps Clinic – Scripps Green Hospital, La Jolla, CA, USA

    • Fei Bao MD

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Guarantor of the article

Gauree G. Konijeti, MD, MPH.

Specific author contributions

GGK and HC provided clinical management and performed the endoscopic procedures. FB provided histopathologic slides. QMN reviewed the clinical history and relevant literature, and wrote the manuscript with input from all authors. All authors participated in critical revision of the manuscript.

Financial support

QMN is supported by Scripps Translational Science Institute (STSI) NIH/NCATS CTSA Award 5 UL1 TR001114 and 5KL2 TR001112 and by a Scripps Clinic Medical Group Research & Education Award. GGK is supported by Scripps Clinic, STSI NIH/NCATS CTSA Award 5 UL1 TR001114 and KL2 TR001112-03 and by a Scripps Clinic Medical Group Research & Education Award.

Potential competing interests

None.

Corresponding authors

Correspondence to Quan M. Nhu MD, PhD or Gauree G. Konijeti MD, MPH.

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DOI

https://doi.org/10.1038/s41395-018-0145-1