Review Article

Clinical narrative: autoimmune hepatitis

  • The American Journal of Gastroenterology (2018)
  • doi:10.1038/s41395-018-0058-z
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Autoimmune hepatitis (AIH) is an inflammatory liver disease that is characterized by circulating autoantibodies, hypergammaglobulinemia, and a lymphoplasmocytic infiltration with interface hepatitis on liver biopsy. Treatment with corticosteroids and other immunosuppressive agents is effective and early diagnosis can result in near-normal life expectancy. Untreated patients, however, can progress to cirrhosis and liver failure. The clinical presentation is heterogeneous and may pose diagnostic and therapeutic dilemmas. This case-based review will address the diagnosis and management of this disease, in addition to difficult but commonly encountered clinical scenarios.

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Author information


  1. Division of Hepatology, Carolinas Healthcare, Charlotte, NC, USA

    • Paul A Schmeltzer MD
    •  & Mark W Russo MD, MPH


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Guarantor of the article

Mark Russo, MD, MPH.

Specific author contributions

MR: concept, writing manuscript, PS: Writing manuscript revisions.

Financial support


Potential competing interests

The authors declare that they have no conflict of interest.

Corresponding author

Correspondence to Mark W Russo MD, MPH.