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Validity of the National Death Index to ascertain the date and cause of death in men having undergone prostatectomy for prostate cancer

Prostate Cancer and Prostatic Diseases volume 22, pages 633–635 (2019)Cite this article

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Abstract

Background

The National Death Index (NDI) is a centralized database containing information from death certificates that are frequently referenced by health and medical investigators to ascertain vital statistics. Yet, it commonly includes misclassified causes of death. Since the NDI is frequently relied upon in studies that evaluate outcomes following radical prostatectomy (RP) for prostate cancer (PC), we evaluated its validity by referencing mortality data from the Shared Equal Access Regional Cancer Hospital (SEARCH) database which is a prospectively managed database of 5009 Veterans who underwent a RP at eight Veterans Affairs medical centers between 1982 and 2016.

Methods

We compared vital status, cause of death and date of death from the SEARCH database with the NDI.

Results

A total of 1312 men in SEARCH were deceased, yet the NDI reported 17% (219) of those men as still alive. Among the 1093 men who had concordant vital status in both SEARCH and NDI, the date of death was an exact match within one day, a week, or 31 days in 94%, 97%, 99%, and 100%, respectively. Of those men coded as dying from prostate cancer in the SEARCH database (n = 105), 12% were coded as having died from non-PC causes in the NDI. Meanwhile, among patients coded by the NDI as having died of PC (n = 139), 34% were coded in SEARCH as having died of non-PC causes.

Conclusions

These findings demonstrate that the NDI provides accurate dates of death, but frequently misclassifies whether a death was due to prostate cancer. Studies that rely upon death certificates, as captured in the NDI, may be unreliable to report prostate cancer-specific mortality rates after prostatectomy.

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Acknowledgements

Support for this study was provided by the NIH/NCI under Award Number P50CA09231 and NIH K24 CA160653.

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Authors and Affiliations

  1. Atlanta Veterans Affairs Health Care System, Atlanta, GA, USA

    Drew Moghanaki

  2. Duke Cancer Institute, Duke University School of Medicine, Durham, NC, USA

    Lauren E. Howard

  3. Durham Veterans Affairs Medical Center, Durham, NC, USA

    Lauren E. Howard, Amanda De Hoedt & Stephen J. Freedland

  4. UCLA Medical Center, Los Angeles, CA, USA

    William J. Aronson

  5. UC San Diego Health System, San Diego, CA, USA

    Christopher J. Kane

  6. Oregon Health & Science University, Portland, OR, USA

    Christopher L. Amling

  7. UC San Francisco Medical Center, San Francisco, CA, USA

    Matthew R. Cooperberg

  8. Augusta University, Augusta, GA, USA

    Martha K. Terris

  9. Cedars-Sinai Medical Center, Los Angeles, CA, USA

    Stephen J. Freedland

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  1. Drew Moghanaki
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  2. Lauren E. Howard
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  7. Matthew R. Cooperberg
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Correspondence to Drew Moghanaki.

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Moghanaki, D., Howard, L.E., De Hoedt, A. et al. Validity of the National Death Index to ascertain the date and cause of death in men having undergone prostatectomy for prostate cancer. Prostate Cancer Prostatic Dis 22, 633–635 (2019). https://doi.org/10.1038/s41391-019-0146-1

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