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Immune-relevant aspects of murine models of head and neck cancer

Oncogene volume 38, pages 3973–3988 (2019)Cite this article

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Abstract

Head and neck cancers (HNCs) cause significant mortality and morbidity. There have been few advances in therapeutic management of HNC in the past 4 to 5 decades, which support the need for studies focusing on HNC biology. In recent years, increased recognition of the relevance of the host response in cancer progression has led to novel therapeutic strategies and putative biomarkers of tumor aggressiveness. However, tumor-immune interactions are highly complex and vary with cancer type. Pre-clinical, in vivo models represent an important and necessary step in understanding biological processes involved in development, progression and treatment of HNC. Rodents (mice, rats, hamsters) are the most frequently used animal models in HNC research. The relevance and utility of information generated by studies in murine models is unquestionable, but it is also limited in application to tumor-immune interactions. In this review, we present information regarding the immune-specific characteristics of the murine models most commonly used in HNC research, including immunocompromised and immunocompetent animals. The particular characteristics of xenograft, chemically induced, syngeneic, transgenic, and humanized models are discussed in order to provide context and insight for researchers interested in the in vivo study of tumor-immune interactions in HNC.

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Acknowledgements

This work was supported by grants from FAPESP 2017/14283-5 (CRJ) and NIH/NIDCR DE027551 and DE022567 (NJD), and UM-FAPESP 2014/50312-1 (NJD and CRJ).

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  1. Department of Diagnosis and Surgery, UNESP-State University of Sao Paulo, School of Dentistry at Araraquara, Araraquara – SP, Brazil

    Carlos Rossa Jr

  2. Department of Periodontics and Oral Medicine, School of Dentistry, Ann Arbor, MI, 48109, USA

    Carlos Rossa Jr & Nisha J. D’Silva

  3. Department of Pathology, Medical School, University of Michigan, Ann Arbor, MI, 48109, USA

    Nisha J. D’Silva

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Rossa, C., D’Silva, N.J. Immune-relevant aspects of murine models of head and neck cancer. Oncogene 38, 3973–3988 (2019). https://doi.org/10.1038/s41388-019-0686-9

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