Abstract
Exposures to environmental chemicals and psychosocial stressors during pregnancy have been individually associated with adverse perinatal outcomes related to birthweight and gestational age, but are not often considered in combination. We review types of psychosocial stressors and instruments used to assess them and classes of environmental chemical exposures that are known to adversely impact perinatal outcomes, and identify studies relevant studies. We discuss the National Institutes of Health’s Environmental influences on Child Health Outcomes (ECHO) program that has combined existing longitudinal cohorts that include more than 50,000 children across the U.S. We describe future opportunities for investigators to use this important new resource for addressing relevant and critical research questions to maternal health. Of the 84 cohorts in ECHO, 38 collected data on environmental chemicals and psychosocial stressors and perinatal outcomes. The diverse ECHO pregnancy cohorts provide capacity to compare regions with distinct place-based environmental and social stressors.
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Acknowledgements
Research reported in this publication was supported by the ECHO program, Office of The Director, NIH, under Award numbers U2COD023375 (Coordinating Center), U24OD023382 (DAC); UG3OD023272 (AMP, TJW, RM-F, and JV); R00ES021470 (AMP), UG3OD023328, UG3OD023316 (CM, SF, and PD), UG3OD023318 (PAB), UG3OD023319 (AB); UG3OD023349, UGOD023271, UGOD023305, P30 ES005022 (ESB); UG3OD023288 (CTM); UG3OD023251 (AA); P42ES017198 (RW); UG30D023349, UG3OD23285 (CS); UG3OD023285 (RF); U24OD023382 (AK). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. The authors wish to thank our ECHO colleagues; the medical, nursing, and program staff; as well as the children and families participating in the ECHO cohorts.
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See Appendix for full listing of collaborators
Appendix
Appendix
The authors wish to thank our ECHO colleagues, the medical, nursing and program staff, as well as the children and families participating in the ECHO cohorts. We also acknowledge the contributions of the following ECHO program collaborators:
ECHO Components
Coordinating Center: Duke Clinical Research Institute, Durham, North Carolina: Benjamin DK, Smith PB, Newby KL
Data Analysis Center: Johns Hopkins University Bloomberg School of Public Health, Baltimore, Maryland: Jacobson LP; Research Triangle Institute, Durham, North Carolina: Parker CB
Person-Reported Outcomes Core: Northwestern University, Evanston, Illinois: Gershon R, Cella D
Children’s Health and Exposure Analysis Resource: Icahn School of Medicine at Mount Sinai, New York City, New York: Teitelbaum SL; Wright RO; Wadsworth Center, Albany, New York: Aldous, KM, RTI International, Research Triangle Park, North Carolina: Fennell T; University of Minnesota, Minneapolis, Minnesota: Hecht SS, Peterson L; Westat, Inc., Rockville, Maryland: O’Brien B
Idea States Pediatric Trials Network: University of Arkansas for Medical Sciences, Little Rock: Lee JY, Snowden J
ECHO Awardees
Albert Einstein College of Medicine, Bronx, New York: Aschner JL, Teitelbaum SL
Brigham & Women's Hospital, Boston, Massachusetts: Litonjua AA
Columbia University, New York, New York: Perera FP
Dartmouth College, Hanover, New Hampshire: Karagas MR,
Drexel University, Philadelphia, Pennsylvania: Newschaffer CJ
Emory University, Atlanta, Georgia: Dunlop AL, Brennan PA, Corwin EJ
Feinstein Institute for Medical Research, Manhasset, New York: Gregersen PK, Diamond B
Harvard Pilgrim Health Care, Boston, Massachusetts: Oken E, Kleinman KP
Icahn School of Medicine at Mount Sinai, Boston, Massachusetts: Wright RO
Kaiser Permanente, Oakland, California: Ferrara A, Croen LA
Massachusetts General Hospital, Boston: Camargo CA
Medical University of South Carolina, Charleston: Vena JE, Wapner R
Memorial Hospital of Rhode Island, Pawtucket: Deoni S, Mueller HG
Michigan State University, East Lansing, Michigan: Paneth N, Barone C, Copeland GE, Elliott MR, Ruden DM
New York State Psychiatric Institute at Columbia University, New York: Duarte CS, Canino GJ, Monk CE, Posner JE
New York University, New York, New York: Blair CB
New York University School of Medicine, New York, New York: Trasande L
Oregon Health & Science University, Portland, Oregon: McEvoy CT, Spindel ER
Northeastern University, Boston, Massachusetts: Alshawabkeh AN
Avera Research, Sioux Falls, South Dakota: Elliott AJ
University of California, Berkeley: Eskenazi B
University of California, Davis: Hertz-Picciotto I, Bennett DH, Schweitzer JB
University of Chicago, Illinois: Claud EC
University of Colorado Anschutz Medical Campus, Aurora, Colorado: Dabelea D
University of Illinois, Urbana: Schantz SL
University of Oregon, Eugene: Leve LD
University of New Mexico, Albuquerque: Lewis JL, MacKenzie D, Begay M-G
University of North Carolina, Chapel Hill: O’Shea M, Fry R
University of Pittsburgh, Pennsylvania: Hipwell AE, Keenan KE
University of Rochester, New York: O’Connor TG, Buss C, Miller RK, Wadhwa PD
University of Southern California, Los Angeles: Gilliland FD, Breton CV
University of Utah, Salt Lake City: Stanford JB, Clark EB, Porucznik C
University of Washington, Seattle: Karr C, Bush NR, Lewinn KZ
University of Wisconsin, Madison: Gern J
Women & Infants Hospital of Rhode Island, Providence: Lester B
ECHO Cohorts
Brigham & Women's Hospital, Boston, Massachusetts: Gold D; Weiss ST
Children's Hospital of Philadelphia, Pennsylvania: Schultz RT
Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio: Hershey N
Columbia University, New York, New York: Miller R; Herbstman JB
Emory University, Atlanta, Georgia: Marsit CJ
George Washington University, Washington D.C.: Ganiban JM
Henry Ford Health System, Detroit, Michigan: Johnson C, Ownby D, Zoratti E
Icahn School of Medicine at Mount Sinai, New York, New York: Stroustrup A
Inova Health Care System, Falls Church, Virginia: Huddleston K
Johns Hopkins University, Baltimore, Maryland: Volk HE
Kennedy Krieger Institute, Baltimore, Maryland: Landa RJ
Medical University of South Carolina, Charleston: Hunt K
Penn State, University Park, Pennsylvania: Neiderhiser JM
Seattle Children's Research Institute, Washington: Sathyanarayana S
University of Arizona, Tucson, Arizona: Martinez F, Wright A
University of California, San Francisco: Keller R; Woodruff TJ
University of California, Davis: Schmidt RJ, Ozonoff S
University of Chicago, Illinois: Andrews B
University of Miami, Coral Gables, Florida: Messinger DS
University of Michigan, Ann Arbor, Michigan: Padmanabhan V
University of North Carolina, Chapel Hill: Piven J
University of Pittsburgh. Magee-Women's Hospital, Pennsylvania: Simhan HN
University of Rochester, Rochester, New York: Pryhuber G
University of Tennessee Health Science Center: Tylavsky FA
University of Washington, Seattle: Dager SR; Maycock D; Stone WL
University of Wisconsin, Madison: Jackson D, Seroogy C
Vanderbilt University, Nashville, Tennessee: Hartert T; Moore P
Washington University, St. Louis, Missouri: Bacharier L; Botteron KN
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Padula, A.M., Monk, C., Brennan, P.A. et al. A review of maternal prenatal exposures to environmental chemicals and psychosocial stressors—implications for research on perinatal outcomes in the ECHO program. J Perinatol 40, 10–24 (2020). https://doi.org/10.1038/s41372-019-0510-y
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DOI: https://doi.org/10.1038/s41372-019-0510-y
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