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Delivery room asphyxia in neonates with ductal-dependent congenital heart disease: a retrospective cohort study

Journal of Perinatology volume 39, pages 1627–1634 (2019)Cite this article

Subjects

Abstract

Objective

We aimed to investigate the clinical course and outcome of newborns with ductal-dependent congenital heart disease (CHD) who suffered from perinatal asphyxia.

Study design

Clinical data of 504 patients with ductal-dependent CHD and perinatal asphyxia were retrospectively analyzed over a 10-year period (2005–2014).

Result

Perinatal asphyxia was diagnosed in 17 (3.4%) patients, comprising two nonoverlapping groups: Five infants with intrauterine acidosis (umbilical artery pH < 7.0), and 12 infants with persistent or deteriorating postnatal depression (Apgar score <6 at 10 min of life). Preoperative (41.7%, p < 0.001) and overall mortality (50.0%, p = 0.001) were increased in infants with asphyxia caused by persistent or deteriorating postnatal depression. Apgar scores at 10 min were independently associated with preoperative (OR 0.479, 95% CI 0.342–0.672, p < 0.001) and overall death (OR 0.655, 95% CI 0.537–0.799, p < 0.001).

Conclusions

Asphyxia caused by postnatally deteriorating depression rather than fetal acidosis is associated with high mortality.

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Authors and Affiliations

  1. Department of Neonatology, Charité - Universitätsmedizin Berlin, Berlin, Germany

    Vinzenz Boos, Liz Kocjancic & Christoph Bührer

  2. Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Centre Berlin, Berlin, Germany

    Vinzenz Boos & Felix Berger

  3. German Centre for Cardiovascular Research (DZHK), Congenital Heart Diseases, Partner Site Berlin, Berlin, Germany

    Felix Berger

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  1. Vinzenz Boos
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  2. Liz Kocjancic
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  3. Felix Berger
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  4. Christoph Bührer
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Correspondence to Vinzenz Boos.

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Boos, V., Kocjancic, L., Berger, F. et al. Delivery room asphyxia in neonates with ductal-dependent congenital heart disease: a retrospective cohort study. J Perinatol 39, 1627–1634 (2019). https://doi.org/10.1038/s41372-019-0474-y

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